CAJ | 학술논문

目的：研究帕金森病(PD)非运动症状的发生和分布情况及其与多种相关因素的关系。方法对68例原发性 PD 患者使用统一 PD 评分量表(uPDRs)、PD 非运动症状30问卷量表(the PD NMS questionnaire,NMSQuest)、日常生活能力量表(ADL)和简易智能量表(MMsE)进行评分,并对非运动症状进行评估。结果所有 PD 患者各个时期病程均有非运动症状的出现,平均每个 PD 患者出现9项左右不同的非运动症状,并且非运动症状的发生与 PD 疾病的进展相关,与 Hoehn and yahr(H-Y)分级呈正相关(P <0.01),与 UPDRsⅢ运动评分呈正相关(P <0.01),且影响患者的生活质量,与 ADL 评分呈负相关 P <0.05),而与年龄、性别、PD 发病类型和左旋多巴每日治疗量无关(P >0.05)。结论非运动症状的发生在 PD 中很普遍,各项发生率随 PD 患者的临床特点及病程进展的情况变化,NMS 发生数与 PD 的疾病严重程度呈正相关,对患者生活质量产生严重影响,需要全面认识和及时干预。
목적：연구파금삼병(PD)비운동증상적발생화분포정황급기여다충상관인소적관계。방법대68례원발성 PD 환자사용통일 PD 평분량표(uPDRs)、PD 비운동증상30문권량표(the PD NMS questionnaire,NMSQuest)、일상생활능역량표(ADL)화간역지능량표(MMsE)진행평분,병대비운동증상진행평고。결과소유 PD 환자각개시기병정균유비운동증상적출현,평균매개 PD 환자출현9항좌우불동적비운동증상,병차비운동증상적발생여 PD 질병적진전상관,여 Hoehn and yahr(H-Y)분급정정상관(P <0.01),여 UPDRsⅢ운동평분정정상관(P <0.01),차영향환자적생활질량,여 ADL 평분정부상관 P <0.05),이여년령、성별、PD 발병류형화좌선다파매일치료량무관(P >0.05)。결론비운동증상적발생재 PD 중흔보편,각항발생솔수 PD 환자적림상특점급병정진전적정황변화,NMS 발생수여 PD 적질병엄중정도정정상관,대환자생활질양산생엄중영향,수요전면인식화급시간예。
Objective To investigate the prevalence,distribution and its influencing factors of non-motor symptoms in Parkinson disease.Methods 68 patients with PD were analyzed use Unified Parkinson Disease Rating Scale(UPDRS),PDNMS Questionnaire,activities of daily living(ADI),and mini-mental state exami-nation(MMSE)to assess non-motor symptoms in patients with Parkinson disease.Results All the patients at different stage of PD,had 9 items of NMS on average.Total NMS score has a significant association with dis-ease severity and progression,positively associated with H-Y stage (P < 0.01 )and UPDRS IIIscore (P <0.01 ),negatively associated with ADL score (P <0.05).Age,sex distribution,daily dose of L-dopa and sub-type of PD are irrelevant facts (P >0.05).Conclusions NMS are very common in PD patients,varies accord-ing to clinical future and course of disease.NMS affect patients'quality of life,and should be well recognized and treated.