中华耳鼻咽喉头颈外科杂志
中華耳鼻嚥喉頭頸外科雜誌
중화이비인후두경외과잡지
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2015年
10期
793-798
,共6页
陈成芳%王明明%樊兆民%张道宫%吕亚峰%王洪亚%王海波
陳成芳%王明明%樊兆民%張道宮%呂亞峰%王洪亞%王海波
진성방%왕명명%번조민%장도궁%려아봉%왕홍아%왕해파
听觉丧失,突发性%胆固醇%甘油三酯类%胆固醇,HDL%胆固醇,LDL%治疗结果
聽覺喪失,突髮性%膽固醇%甘油三酯類%膽固醇,HDL%膽固醇,LDL%治療結果
은각상실,돌발성%담고순%감유삼지류%담고순,HDL%담고순,LDL%치료결과
Hearing loss,sudden%Cholesterol%Triglycerides%Cholesterol,HDL%Cholesterol,LDL%Treatment outcome
目的 探讨突发性聋患者血脂指标与突聋的发病及疗效是否存在相关关系.方法 对2013年12月至2015年2月共258例突发性聋患者的临床资料进行回顾性分析,观察不同听力损失程度(轻度、中度、重度和极重度)、听力曲线类型(低频下降型、高频下降型、平坦型和全聋型)及疗效(痊愈、显效、有效和无效)的突发性聋患者血浆中各项血脂指标[包括总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)和非高密度脂蛋白胆固醇(non-highdensity lipoprotein,Non-HDL-C)等]的分布特征,使用SPSS 22.0统计软件进行方差分析、卡方检验及多元回归分析.结果 轻度聋患者血浆TG浓度明显低于重度和极重度聋患者,差异具有统计学意义(P值分别为0.017和0.007).四种听力曲线类型和血脂指标之间均无相关性(P值均＞0.05).有效组和无效组Non-HDL-C明显高于痊愈组(P值分别为0.021和0.026),显效和无效组的TC明显高于痊愈组(P值分别为0.049和0.042),有效组的TG明显高于痊愈组(P =0.014).结论 TG与突发性聋的听力损失程度呈正相关,Non-HDL-C、TC和TG与突发性聋患者的疗效呈负相关,可为判断预后提供参考.
目的 探討突髮性聾患者血脂指標與突聾的髮病及療效是否存在相關關繫.方法 對2013年12月至2015年2月共258例突髮性聾患者的臨床資料進行迴顧性分析,觀察不同聽力損失程度(輕度、中度、重度和極重度)、聽力麯線類型(低頻下降型、高頻下降型、平坦型和全聾型)及療效(痊愈、顯效、有效和無效)的突髮性聾患者血漿中各項血脂指標[包括總膽固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、高密度脂蛋白膽固醇(high density lipoprotein cholesterol,HDL-C)、低密度脂蛋白膽固醇(low density lipoprotein cholesterol,LDL-C)和非高密度脂蛋白膽固醇(non-highdensity lipoprotein,Non-HDL-C)等]的分佈特徵,使用SPSS 22.0統計軟件進行方差分析、卡方檢驗及多元迴歸分析.結果 輕度聾患者血漿TG濃度明顯低于重度和極重度聾患者,差異具有統計學意義(P值分彆為0.017和0.007).四種聽力麯線類型和血脂指標之間均無相關性(P值均＞0.05).有效組和無效組Non-HDL-C明顯高于痊愈組(P值分彆為0.021和0.026),顯效和無效組的TC明顯高于痊愈組(P值分彆為0.049和0.042),有效組的TG明顯高于痊愈組(P =0.014).結論 TG與突髮性聾的聽力損失程度呈正相關,Non-HDL-C、TC和TG與突髮性聾患者的療效呈負相關,可為判斷預後提供參攷.
목적 탐토돌발성롱환자혈지지표여돌롱적발병급료효시부존재상관관계.방법 대2013년12월지2015년2월공258례돌발성롱환자적림상자료진행회고성분석,관찰불동은력손실정도(경도、중도、중도화겁중도)、은력곡선류형(저빈하강형、고빈하강형、평탄형화전롱형)급료효(전유、현효、유효화무효)적돌발성롱환자혈장중각항혈지지표[포괄총담고순(total cholesterol,TC)、감유삼지(triglyceride,TG)、고밀도지단백담고순(high density lipoprotein cholesterol,HDL-C)、저밀도지단백담고순(low density lipoprotein cholesterol,LDL-C)화비고밀도지단백담고순(non-highdensity lipoprotein,Non-HDL-C)등]적분포특정,사용SPSS 22.0통계연건진행방차분석、잡방검험급다원회귀분석.결과 경도롱환자혈장TG농도명현저우중도화겁중도롱환자,차이구유통계학의의(P치분별위0.017화0.007).사충은력곡선류형화혈지지표지간균무상관성(P치균＞0.05).유효조화무효조Non-HDL-C명현고우전유조(P치분별위0.021화0.026),현효화무효조적TC명현고우전유조(P치분별위0.049화0.042),유효조적TG명현고우전유조(P =0.014).결론 TG여돌발성롱적은력손실정도정정상관,Non-HDL-C、TC화TG여돌발성롱환자적료효정부상관,가위판단예후제공삼고.
Objective We aimed to determine whether blood lipid parameters were related to the severity and the prognosis of idiopathic sudden sensorineural hearing loss(ISSNHL) patients.Methods A retrospective cohort study of 258 patients with ISSNHL from December 2013 to February 2015.The distribution characteristics of lipids [total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C), Non-high-density lipoprotein cholesterol (Non-HDL-C), et al] in different degree of deafness (mild, moderate, severe, and profound), hearing curve types (low frequency, high frequency, full range frequency, and completely deafness type) and prognosis of recovery (complete, partial, slight, and no recovery) were analyzed by IBM SPSS 22.0 ANOVA analysis, chi square test and multiple regression analysis.Results TG level in mild hearing loss group was significantly lower than that in severe and profound hearing loss group (P =0.017 and P =0.007).There were no correlation between curve types and lipid indexes (P ＞ 0.05).Non-HDL-C level was elevated in no recovery and slight recovery groups (P =0.026 and 0.021).TC levels in partial recovery group and no recovery group were significantly higher than that in the complete recovery group (P =0.049 and 0.042) ,TG was higher in slight recovery group (P =0.014).Conclusions TG has significant correlation with the severity of hearing loss.There are negative correlations between hearing recovery and Non-HDL-C, TC and TG levels.Non-HDL-C, TC and TG might be a prognostic factor for treatment outcome in ISSNHL patients.
