CAJ | 학술논문

目的：探讨反复输血后不完全抗体的阳性率及其临床意义。方法：选择2013年6月-2015年3月于本院进行反复输血的1600例输血者作为观察组，选择同期进行首次输血的1600例输血者作为对照组。分别对两组输血者的血液标本进行不完全抗体的筛查，观察不完全抗体阳性的发生情况及其与不良输血反应的关系，对观察组的抗体类型进行分析，观察其在不同的输血次数下抗-E、抗-D、自身抗体、抗-Ec、抗-C、抗-c、抗-e、抗-M、抗-JKa以及不明抗体的阳性发生情况。结果：观察组不完全抗体阳性率明显高于对照组，比较差异有统计学意义（P<0.05）；输血3~5次与6~10次的不完全抗体阳性率显著低于输血15次以上，比较差异均有统计学意义（P<0.05）；不完全抗体阳性者不良输血反应发生率明显高于不完全抗体阴性者，比较差异有统计学意义（P<0.05）；观察组中输血3~5次的患者共出现3种抗体，6~10次的患者共出现4种抗体，11~15次的患者共出现6种抗体，15次以上的患者共出现7种抗体。结论：输血次数越多输血者不完全抗体阳性发生率及输血反应发生率则越高，抗体种类也越多，只有控制输血次数，才能保证较好的输血效果。
목적：탐토반복수혈후불완전항체적양성솔급기림상의의。방법：선택2013년6월-2015년3월우본원진행반복수혈적1600례수혈자작위관찰조，선택동기진행수차수혈적1600례수혈자작위대조조。분별대량조수혈자적혈액표본진행불완전항체적사사，관찰불완전항체양성적발생정황급기여불량수혈반응적관계，대관찰조적항체류형진행분석，관찰기재불동적수혈차수하항-E、항-D、자신항체、항-Ec、항-C、항-c、항-e、항-M、항-JKa이급불명항체적양성발생정황。결과：관찰조불완전항체양성솔명현고우대조조，비교차이유통계학의의（P<0.05）；수혈3~5차여6~10차적불완전항체양성솔현저저우수혈15차이상，비교차이균유통계학의의（P<0.05）；불완전항체양성자불량수혈반응발생솔명현고우불완전항체음성자，비교차이유통계학의의（P<0.05）；관찰조중수혈3~5차적환자공출현3충항체，6~10차적환자공출현4충항체，11~15차적환자공출현6충항체，15차이상적환자공출현7충항체。결론：수혈차수월다수혈자불완전항체양성발생솔급수혈반응발생솔칙월고，항체충류야월다，지유공제수혈차수，재능보증교호적수혈효과。
Objective:To analyze the positive rate and clinical significance of incomplete antibody after repeated transfusion.Method:1600 people with repeated blood transfusion in our hospital from June 2013 to March 2015 were selected as the observation group.1600 people who received blood transfusion for the first time were selected as the control group at the same time.The incomplete antibody in the blood samples of the two groups were screened.The positive rate of incomplete antibody and its relationship with adverse reactions of blood transfusion were observed.The antibody types of the observation group were analyzed,the positive situation of anti-D,autoantibodies,anti-Ec,anti-C,anti-c,anti-e, anti-M,anti-JKa and unknown antibody in patients with different blood transfusion times were observed.Result:The positive rate of incomplete antibody in the observation group was significantly higher than that in the control group,the difference was statistically significant (P<0.05).The positive rates of incomplete antibody in patients with 3 to 5 times and 6 to 10 times of blood transfusion were lower than that in patients with more than 15 times of blood transfusion, the differences were statistically significant(P<0.05).The adverse reaction of blood transfusion in patients with positive incomplete antibody was higher than that in patients with negative incomplete antibody,the difference was statistically significant (P<0.05).In the observation group,patients with 3 to 5 times of blood transfusion had 3 kinds of antibodies,patients with 6 to 10 times of blood transfusion had 4 kinds of antibodies,patients with 11 to 15 times of blood transfusion had 6 kinds of antibodies,patients with more than 15 times of blood transfusion had 7 kinds of antibodies.Conclusion:According with the increasing of the times of transfusion,the occurrence rates of positive incomplete antibody and the adverse reaction of blood transfusion increase,the kinds of antibodies also increase.The times of blood transfusion shall be controlled in order to ensure the better effect of blood transfusion.