中国医学创新
中國醫學創新
중국의학창신
Medical Innovation of China
2015年
29期
12-14
,共3页
左晓旭%朱袭嘉%李盛国%罗喜顺%甘泽林%王海鹏
左曉旭%硃襲嘉%李盛國%囉喜順%甘澤林%王海鵬
좌효욱%주습가%리성국%라희순%감택림%왕해붕
黏蛋白2%结肠腺瘤%结肠癌
黏蛋白2%結腸腺瘤%結腸癌
점단백2%결장선류%결장암
MUC2%Colorectal adenoma%Colorectal carcinoma
目的:研究黏蛋白(MUC2)在结肠正常组织、结肠良性腺瘤组织和结肠癌组织中的表达状况,以及MUC2的表达情况与结肠癌患者临床资料的关联。方法:选择2011年3月-2015年3月本院手术切除的结肠正常组织15例,结肠良性腺瘤组织41例及结肠癌组织121例,应用免疫组织化学技术检测MUC2在不同组织中的表达。结果:(1)MUC2在结肠正常组织、结肠良性腺瘤组织和结肠癌组织中的阳性表达率分别为100%(15/15)、73.17%(30/41)和46.28%(56/121),不同组织中MUC2阳性表达率比较,差异有统计学意义(P<0.01)。(2)MUC2高表达的结肠癌患者组织分型、淋巴结转移及肿瘤分期均优于MUC2低表达患者,比较差异均有统计学意义(P<0.05)。结论:结肠癌中MUC2的表达状况与组织分型、淋巴结转移和肿瘤分期有关。MUC2的表达下调可能参与了结肠癌的发生、发展、浸润和转移等过程。
目的:研究黏蛋白(MUC2)在結腸正常組織、結腸良性腺瘤組織和結腸癌組織中的錶達狀況,以及MUC2的錶達情況與結腸癌患者臨床資料的關聯。方法:選擇2011年3月-2015年3月本院手術切除的結腸正常組織15例,結腸良性腺瘤組織41例及結腸癌組織121例,應用免疫組織化學技術檢測MUC2在不同組織中的錶達。結果:(1)MUC2在結腸正常組織、結腸良性腺瘤組織和結腸癌組織中的暘性錶達率分彆為100%(15/15)、73.17%(30/41)和46.28%(56/121),不同組織中MUC2暘性錶達率比較,差異有統計學意義(P<0.01)。(2)MUC2高錶達的結腸癌患者組織分型、淋巴結轉移及腫瘤分期均優于MUC2低錶達患者,比較差異均有統計學意義(P<0.05)。結論:結腸癌中MUC2的錶達狀況與組織分型、淋巴結轉移和腫瘤分期有關。MUC2的錶達下調可能參與瞭結腸癌的髮生、髮展、浸潤和轉移等過程。
목적:연구점단백(MUC2)재결장정상조직、결장량성선류조직화결장암조직중적표체상황,이급MUC2적표체정황여결장암환자림상자료적관련。방법:선택2011년3월-2015년3월본원수술절제적결장정상조직15례,결장량성선류조직41례급결장암조직121례,응용면역조직화학기술검측MUC2재불동조직중적표체。결과:(1)MUC2재결장정상조직、결장량성선류조직화결장암조직중적양성표체솔분별위100%(15/15)、73.17%(30/41)화46.28%(56/121),불동조직중MUC2양성표체솔비교,차이유통계학의의(P<0.01)。(2)MUC2고표체적결장암환자조직분형、림파결전이급종류분기균우우MUC2저표체환자,비교차이균유통계학의의(P<0.05)。결론:결장암중MUC2적표체상황여조직분형、림파결전이화종류분기유관。MUC2적표체하조가능삼여료결장암적발생、발전、침윤화전이등과정。
Objective:To investigate the expression of MUC2 in normal colorectal tissue,colorectal adenomas and colorectal carcinomas,and to explore the relation between the expression of MUC2 and its associated clinical data. Method:15 cases of normal colorectal tissues,41 cases of colorectal adenomas tissues and 121 cases of colorectal carcinomas tissues in our hospital were selected from March 2011 to March 2015.The expression of MUC2 in different tissues were detected by immunohistochemistry.Result:(1)The positive expression rates of MUC2 in normal colorectal tissues,colorectal adenomas tissues and colorectal carcinomas tissues were 100%(15/15),73.17%(30/41) and 46.28%(56/121) respectively.The differences of the positive expression rates in different tissues were statistically significant(P<0.01).(2)The histological differentiation,lymph node metastasis and tumor stage in patients with high expression rates of MUC2 were better than those in patients with low expression rates of MUC2,the differences were statistically significant(P<0.05).Conclusion:The expression of MUC2 in colorectal carcinomas has relationships with histological differentiation,lymph node metastasis and tumor stage.The down-regulation of MUC2 expression may play a role in the carcinogenesis,progression,infiltration,metastasis and other processes of colorectal carcinomas.