中国医学创新
中國醫學創新
중국의학창신
Medical Innovation of China
2015年
29期
80-82,83
,共4页
去甲肾上腺素%多巴胺%感染性休克%胃黏膜pH值
去甲腎上腺素%多巴胺%感染性休剋%胃黏膜pH值
거갑신상선소%다파알%감염성휴극%위점막pH치
Norepinephrine%Dopamine%Septic shock%The pH value of gastric mucosa
目的：探讨去甲肾上腺素、多巴胺对感染性休克患者胃黏膜pH值（Phi）的影响。方法：选择64例感染性休克患者，按所使用的血管活性药物分为两组，A组为去甲肾上腺素组，B组为多巴胺组，每组各32例。观察用药前和用药后6 h血流动力学指标的改变，同时观察用药前和用药后6、12、24、48 h胃黏膜pH值的变化。结果：两组用药前血流动力学指标和胃黏膜pH值比较差异无统计学意义（P>0.05）。用药后6 h后，两组的平均动脉压（MAP）明显升高但差异无统计学意义（P>0.05）；两组的中心静脉压（CVP）与中心静脉血氧饱和度（ScvO2）均升高，且A组高于B组，B组心率（HR）明显高于A组，两组比较差异均有统计学意义（P<0.05）。A组用药后6、12、24、48 h胃黏膜pH值均明显升高，治疗前后比较差异均有统计学意义（P<0.01），B组治疗前后比较差异无统计学意义（P>0.05）。结论：去甲肾上腺素、多巴胺均可改善感染性休克患者全身血流动力学状态，但去甲肾上腺素优于多巴胺，去甲肾上腺素较多巴胺可使胃黏膜pH值（Phi）明显升高。
目的：探討去甲腎上腺素、多巴胺對感染性休剋患者胃黏膜pH值（Phi）的影響。方法：選擇64例感染性休剋患者，按所使用的血管活性藥物分為兩組，A組為去甲腎上腺素組，B組為多巴胺組，每組各32例。觀察用藥前和用藥後6 h血流動力學指標的改變，同時觀察用藥前和用藥後6、12、24、48 h胃黏膜pH值的變化。結果：兩組用藥前血流動力學指標和胃黏膜pH值比較差異無統計學意義（P>0.05）。用藥後6 h後，兩組的平均動脈壓（MAP）明顯升高但差異無統計學意義（P>0.05）；兩組的中心靜脈壓（CVP）與中心靜脈血氧飽和度（ScvO2）均升高，且A組高于B組，B組心率（HR）明顯高于A組，兩組比較差異均有統計學意義（P<0.05）。A組用藥後6、12、24、48 h胃黏膜pH值均明顯升高，治療前後比較差異均有統計學意義（P<0.01），B組治療前後比較差異無統計學意義（P>0.05）。結論：去甲腎上腺素、多巴胺均可改善感染性休剋患者全身血流動力學狀態，但去甲腎上腺素優于多巴胺，去甲腎上腺素較多巴胺可使胃黏膜pH值（Phi）明顯升高。
목적：탐토거갑신상선소、다파알대감염성휴극환자위점막pH치（Phi）적영향。방법：선택64례감염성휴극환자，안소사용적혈관활성약물분위량조，A조위거갑신상선소조，B조위다파알조，매조각32례。관찰용약전화용약후6 h혈류동역학지표적개변，동시관찰용약전화용약후6、12、24、48 h위점막pH치적변화。결과：량조용약전혈류동역학지표화위점막pH치비교차이무통계학의의（P>0.05）。용약후6 h후，량조적평균동맥압（MAP）명현승고단차이무통계학의의（P>0.05）；량조적중심정맥압（CVP）여중심정맥혈양포화도（ScvO2）균승고，차A조고우B조，B조심솔（HR）명현고우A조，량조비교차이균유통계학의의（P<0.05）。A조용약후6、12、24、48 h위점막pH치균명현승고，치료전후비교차이균유통계학의의（P<0.01），B조치료전후비교차이무통계학의의（P>0.05）。결론：거갑신상선소、다파알균가개선감염성휴극환자전신혈류동역학상태，단거갑신상선소우우다파알，거갑신상선소교다파알가사위점막pH치（Phi）명현승고。
Objective:To investigate the effect of Norepinephrine and Dopamine in the pH value of gastric mucosa in patients with septic shock.Method:64 patients with septic shock were selected and divided into Norepinephrine treatment group(group A) and Dopamine treatment group(group B),32 cases in each group.The change of hemodynamic index before and after medication 6 hours and the pH value of gastric mucosa before and after medication 6,12,24 and 48 hours were observed.Result:Before medication,the hemodynamic index and the pH value of gastric mucosa of two groups had no significant differences(P>0.05).After treatment,mean arterial pressure(MAP) of two groups significantly improved,but the difference was no statistically significant(P>0.05).The central venous pressure (CVP)and central venous oxygen saturation(ScvO2) of two groups were significantly improved and group A was higher than group B,heart rate of group B increased significantly than group A,the differences were statistically significant (P<0.05).The pH value of gastric mucosa after medication 6,12,24,and 48 hours in group A were significantly improved than before medication, the differences were statistically significant(P<0.05),there was no significant change of that in group B(P>0.05).Conclusion:Norepinephrine and Dopamine can all improve the whole body hemodynamic state in patients with septic shock,but Norepinephrine is better than Dopamine,Norepinephrine can improve the pH value of gastric mucosa than Dopamine.
