中国医药导刊
中國醫藥導刊
중국의약도간
Chinese Journal of Medical Guide
2015年
9期
875-877
,共3页
带状疱疹%神经阻滞%疼痛
帶狀皰疹%神經阻滯%疼痛
대상포진%신경조체%동통
Herpes zoster%Nerve block%Pain
目的:探讨神经阻滞治疗带状疱疹疼痛的临床疗效及对患者血清Th细胞因子的影响.方法:将我院2012年6月~2014年8月收治的72例带状疱疹疼痛患者作为研究对象,采用随机数字表法分为对照组和观察组.对照组采用药物治疗,观察组在对照组的基础上加神经阻滞法治疗.于治疗后进行视觉模拟评分(VAS)、汉密顿焦虑量表(HAMA)评分和疗效评价,经酶联免疫吸附法测定细胞因子.结果:与对照组比较,观察组治疗后2周、3周和5周的VAS评分明显降低(P<0.05);治疗后5周,观察组总有效率(89.89%)和显效率(63.89%)均明显高于对照组(66.67%,38.89%),HAMA量表总分低于对照组(P<0.05).患者血清中的TNF-α、IL-2、IL-4细胞因子治疗前后无明显差异(P>0.05).结论:带状疱疹疼痛患者机体细胞免疫功能减退,神经节内潜伏的病毒易被激活,神经阻滞联合药物治疗能迅速缓解疼痛并有预防作用,但对机体免疫调节功能无明显作用.
目的:探討神經阻滯治療帶狀皰疹疼痛的臨床療效及對患者血清Th細胞因子的影響.方法:將我院2012年6月~2014年8月收治的72例帶狀皰疹疼痛患者作為研究對象,採用隨機數字錶法分為對照組和觀察組.對照組採用藥物治療,觀察組在對照組的基礎上加神經阻滯法治療.于治療後進行視覺模擬評分(VAS)、漢密頓焦慮量錶(HAMA)評分和療效評價,經酶聯免疫吸附法測定細胞因子.結果:與對照組比較,觀察組治療後2週、3週和5週的VAS評分明顯降低(P<0.05);治療後5週,觀察組總有效率(89.89%)和顯效率(63.89%)均明顯高于對照組(66.67%,38.89%),HAMA量錶總分低于對照組(P<0.05).患者血清中的TNF-α、IL-2、IL-4細胞因子治療前後無明顯差異(P>0.05).結論:帶狀皰疹疼痛患者機體細胞免疫功能減退,神經節內潛伏的病毒易被激活,神經阻滯聯閤藥物治療能迅速緩解疼痛併有預防作用,但對機體免疫調節功能無明顯作用.
목적:탐토신경조체치료대상포진동통적림상료효급대환자혈청Th세포인자적영향.방법:장아원2012년6월~2014년8월수치적72례대상포진동통환자작위연구대상,채용수궤수자표법분위대조조화관찰조.대조조채용약물치료,관찰조재대조조적기출상가신경조체법치료.우치료후진행시각모의평분(VAS)、한밀돈초필량표(HAMA)평분화료효평개,경매련면역흡부법측정세포인자.결과:여대조조비교,관찰조치료후2주、3주화5주적VAS평분명현강저(P<0.05);치료후5주,관찰조총유효솔(89.89%)화현효솔(63.89%)균명현고우대조조(66.67%,38.89%),HAMA량표총분저우대조조(P<0.05).환자혈청중적TNF-α、IL-2、IL-4세포인자치료전후무명현차이(P>0.05).결론:대상포진동통환자궤체세포면역공능감퇴,신경절내잠복적병독역피격활,신경조체연합약물치료능신속완해동통병유예방작용,단대궤체면역조절공능무명현작용.
Objective: To investigate the effect of nerve blocking in the treatment of herpetic zoster pain and its influence on the serum levels of Th cytokines.Methods:From Jun 2012 to Aug 2014,72 patients with herpes zoster pain in our hospital were randomly divided into control group and observation group.The control group was treated with medicine, while the observation group was treated with nerve block on the basis of the control group. In after the treatment by visual analogue scale (VAS),Hamilton Anxiety Scale (HAMA) score and efficacy evaluation,by enzyme linked immunosorbent assay determination of cytokine.Results:Compared with the control group,the P<0.05 score of the observation group was significantly lower (VAS) after 2 weeks, 3 weeks and 5 weeks after treatment, the total effective rate (89.89%) and 5 (63.89%) were significantly higher than those in the control group (38.89%, 66.67%), and the total score of HAMA was lower than that of the control group (P<0.05).There was no significant difference in serum TNF-α, IL-2, and IL-4 cells (P>0.05).Conclusion:The cellular immune function in patients with herpes zoster pain is decreased, the latent virus in the ganglion is activated, and the nerve block combined with drug therapy can quickly relieve pain and prevent it.
