CAJ | 학술논문

目的评价盐酸米诺环素不同给药方式治疗牙周牙髓综合症的临床疗效和安全性. 方法将100例牙周牙髓综合征患者随机分为试验组50例和对照组50例. 对照组在牙周袋内局部予以盐酸米诺环素结合传统根管治疗,每周一次,连续使用6周;试验组经根管途径予以盐酸米诺环素结合现代根管治疗术进行治疗,5~7d复诊一次,经一至数次换药达到根管充填标准后,充填根管. 于手术前后观察菌斑指数、牙周袋探诊深度、探诊后出血指数及牙龈指数;于术后即刻、术后3 ,6个月评价临床疗效并统计不良反应发生率. 结果治疗后,2组患者菌斑指数、牙周袋探诊深度、探诊后出血指数和牙龈指数均较治疗前显著下降( P<0.05 ) ,且试验组的菌斑指数、牙周袋探诊深度、探诊后出血指数和牙龈指数均明显低于对照组( P<0.05 ). 试验组和对照组治疗后术后即刻、术后3 ,6个月治疗的总有效率分别为94.00%和82.00%( P<0.05 )、92.00%和80.00%( P<0.05 )、92.00%和76.00%( P<0.05 ). 2组患者的不良反应发生率比较差异无统计学意义( P>0.05 ). 结论经根管途径予以盐酸米诺环素结合现代根管治疗术治疗牙周牙髓综合征有利于提高牙周牙髓综合征的临床疗效,值得在临床上推广使用.
목적 평개염산미낙배소불동급약방식치료아주아수종합증적림상료효화안전성. 방법 장100례아주아수종합정환자수궤분위시험조50례화대조조50례. 대조조재아주대내국부여이염산미낙배소결합전통근관치료,매주일차,련속사용6주;시험조경근관도경여이염산미낙배소결합현대근관치료술진행치료,5~7d복진일차,경일지수차환약체도근관충전표준후,충전근관. 우수술전후관찰균반지수、아주대탐진심도、탐진후출혈지수급아간지수;우술후즉각、술후3 ,6개월평개림상료효병통계불량반응발생솔. 결과 치료후,2조환자균반지수、아주대탐진심도、탐진후출혈지수화아간지수균교치료전현저하강( P<0.05 ) ,차시험조적균반지수、아주대탐진심도、탐진후출혈지수화아간지수균명현저우대조조( P<0.05 ). 시험조화대조조치료후술후즉각、술후3 ,6개월치료적총유효솔분별위94.00%화82.00%( P<0.05 )、92.00%화80.00%( P<0.05 )、92.00%화76.00%( P<0.05 ). 2조환자적불량반응발생솔비교차이무통계학의의( P>0.05 ). 결론 경근관도경여이염산미낙배소결합현대근관치료술치료아주아수종합정유리우제고아주아수종합정적림상료효,치득재림상상추엄사용.
Objective To evaluate the clinical efficacy and safety of mi-nocycline via root canal combined with modern root canal therapy in the treatment of periodontal pulp syndrome .Methods One hundred patients with periodontal pulp syndrome were randomly divided into treatment group ( n=50 ) and control group ( n=50 ) .Patients in control group were treated with minocycline via periodontal pocket combined with tradi-tional root canal therapy , once a week , 6 weeks.Patients in treatment group were treated with minocycline via root canal combined with modern root canal therapy , 5-7 d visit once , root canal was filled after one to several dressing to achieve root canal standard .The plaque index , tooth mobility, probing pocket depth , bleeding on probing index and gingival index were observed before and after surgery .The clinical efficacy was evaluated at the right moment , 3 months and 6 months after surgery , and the adverse drug reactions were counted .Results The plaque indexes , periodontal pocket diagnose depth , bleeding index and gingival index of patients in both groups were significantly descent after treatment( P<0.05 ) , and in treatment group , they were significantly lower than those in control group ( P<0.05 ) .The total curative effective rates in treatment group and control group were 94.00%and 82.00%( P<0.05) instantly after opera-tion, 92.00%and 80.00%(P<0.05) at three months after operation , 92.00%and 76.00%(P<0.05) at six months after operation.The incidence of adverse drug reactions of the two groups was compared and the difference was not statistical-ly significant (P>0.05).Conclusion Minocycline via root canal combined with modern root canal therapy can improve clinical effect of periodontal pulp syndrome , and suit to widely using in clinic .