CAJ | 학술논문

目的评价舍曲林联合心理疗法治疗青少年强迫症的临床疗效及安全性.方法 110例青少年强迫症患者随机分为试验组及对照组,各55例.2组均给予舍曲林治疗,每次50~100 mg,持续12周;试验组在此基础上接受心理治疗. 比较2组患者的临床疗效. 结果试验组总有效率为85.5%,对照组为63.6%,试验组显著高于对照组( P<0.05 ). 2组患者治疗后耶鲁布朗强迫量表评分、汉密尔顿焦虑量表评分均显著降低,试验组降低更为明显( P<0.05 ). 2组患者治疗期间副反应量表评分均未见明显变化( P>0.05 ) ,试验组治疗期间副反应量表评分显著低于对照组( P<0.05 ). 结论舍曲林联合心理治疗能够明显改善青少年强迫症患者临床症状,且可减轻治疗不良反应,具有良好的疗效及安全性.
목적 평개사곡림연합심리요법치료청소년강박증적림상료효급안전성.방법 110례청소년강박증환자수궤분위시험조급대조조,각55례.2조균급여사곡림치료,매차50~100 mg,지속12주;시험조재차기출상접수심리치료. 비교2조환자적림상료효. 결과 시험조총유효솔위85.5%,대조조위63.6%,시험조현저고우대조조( P<0.05 ). 2조환자치료후야로포랑강박량표평분、한밀이돈초필량표평분균현저강저,시험조강저경위명현( P<0.05 ). 2조환자치료기간부반응량표평분균미견명현변화( P>0.05 ) ,시험조치료기간부반응량표평분현저저우대조조( P<0.05 ). 결론 사곡림연합심리치료능구명현개선청소년강박증환자림상증상,차가감경치료불량반응,구유량호적료효급안전성.
Objective To analyze the clinical effect and safety of sertra-line plus psychotherapy on adolescent obsessive -compulsive disorder pa-tients.Methods One hundred and ten cases of adolescent patients with obsessive -compulsive disorder were randomly divided into treatment group and control group , each group 55 cases.Sertraline was given to the two groups , treatment group given psychological treatment on the basis . To compare the clinical effect of the two groups .Results Total efficien-cy in treatment group was 85.5%, significantly higher than that in con-trol group , which was 63.6%( P<0.05 ) .The scores of Yale -Brown obsessive -compulsive scale and Hamilton depression scale after treat-ment in the two groups were significantly lower than before treatment , and the treatment group was more significantly ( P<0.05 ) .During the treatment, the treatment emergent symptom scale ( TESS) scores had no significant difference of the two groups ( P >0.05 ) , but the treatment group was significantly lower than control group (P<0.05).Conclusion Seculin combined with psychological treatment can improve the clinical symptoms of adolescents with obsessive -compulsive disorder , and can reduce the incidence of adverse reactions , with good efficacy and safety .