CAJ | 학술논문

列举高血压动物模型的分类及特点,探讨抗高血压药物研发非临床药效学关注的问题,包括模型选择、观察指标设置、阳性对照药的选择等,关注综合评价,考虑相关领域药物开发及临床需求,探讨抗高血压药物非临床药效学研究与评价思路.
열거고혈압동물모형적분류급특점,탐토항고혈압약물연발비림상약효학관주적문제,포괄모형선택、관찰지표설치、양성대조약적선택등,관주종합평개,고필상관영역약물개발급림상수구,탐토항고혈압약물비림상약효학연구여평개사로.
To list the classification and characteristics of non -clinical hypertension models , to investigate the existing problems of nonclinical efficacy in drug discovery , including selection of animal model , parameter , positive control and other test plan factors , which should be paid attention to the combined evaluation , and with the consideration of drug development and clinical need in the field , to propose the nonclinical efficacy ideas on drug development and evaluation .