CAJ | 학술논문

糖尿病心肌病( DCM)是一种以心肌结构和功能重构为特征的特异性心肌病,其发生不依赖于冠心病、高血压和其他心脏疾病. 影响糖尿病心肌病的因素很多,如代谢紊乱、微血管病变、钙转运缺陷及自主神经病变等因素,但其发病机制尚不清楚. 微小RNA ( miRNAs )是一种转录后调节基因表达的非编码小RNA,参与调节糖尿病心肌病病理生理过程中的多个环节. 本文将主要阐述miRNAs与糖尿病心肌病的一些病理性改变(如心肌肥大、纤维化、细胞凋亡、代谢失调、心律失常)的关系及作用.
당뇨병심기병( DCM)시일충이심기결구화공능중구위특정적특이성심기병,기발생불의뢰우관심병、고혈압화기타심장질병. 영향당뇨병심기병적인소흔다,여대사문란、미혈관병변、개전운결함급자주신경병변등인소,단기발병궤제상불청초. 미소RNA ( miRNAs )시일충전록후조절기인표체적비편마소RNA,삼여조절당뇨병심기병병리생리과정중적다개배절. 본문장주요천술miRNAs여당뇨병심기병적일사병이성개변(여심기비대、섬유화、세포조망、대사실조、심률실상)적관계급작용.
Diabetic cardiomyopathy ( DCM) is characterized by myocar-dial structural remodeling and functional remodeling as a specific cardio-myopathy in people with diabetes , which is not dependent on coronary heart disease , hypertension and other heart diseases .It was found that a plenty of factors can affect diabetic cardiomyopathy , such as metabolic disorders , microvascular disease , calcium transport , autonomic neuropa-thy, etc, but its mechanism of pathogenesis is unclear . MicroRNAs ( MiRNAs) , is a small non -coding RNA molecule , which functions in RNA silencing and post -transcriptional regulation of gene expression .It was involved in regulating a variety of cardiovascular diseases , such as diabetic cardiomyopathy .This article will conclude role of miRNAs in the pathological changes of diabetic cardiomyopathy such as cardiac hypertro-phy, fibrosis, apoptosis, metabolism disorders and cardiac arrhythmias .