CAJ | 학술논문

秀丽隐杆线虫在受到病原菌感染时，会迅速激活固有免疫。神经免疫间的交流可以通过神经系统释放神经递质、神经肽及激素来调控固有免疫反应，包括已知的多巴胺信号通路、TGF-β信号通路和胰岛素信号通路。近年来的研究表明，NPR-1神经环路也参与固有免疫的调控，并且三个体液调控神经元 AQR、PQR 和 URX 是通过 NPR-1神经环路调节固有免疫的。线虫的神经系统只有302个神经元，结构也相对简单，线虫的 npr-1基因可编码与哺乳动物神经肽 Y(neuropeptideY，NPY)具有受体相似的 GPCR，这些优势为研究高等生物神经免疫间交流的分子机制提供了基础。本文就体液调控神经元在调控秀丽线虫固有免疫方面展开讨论，希望可以为高等生物神经免疫间的调节机制提供重要的思路和方法。
수려은간선충재수도병원균감염시，회신속격활고유면역。신경면역간적교류가이통과신경계통석방신경체질、신경태급격소래조공고유면역반응，포괄이지적다파알신호통로、TGF-β신호통로화이도소신호통로。근년래적연구표명，NPR-1신경배로야삼여고유면역적조공，병차삼개체액조공신경원 AQR、PQR 화 URX 시통과 NPR-1신경배로조절고유면역적。선충적신경계통지유302개신경원，결구야상대간단，선충적 npr-1기인가편마여포유동물신경태 Y(neuropeptideY，NPY)구유수체상사적 GPCR，저사우세위연구고등생물신경면역간교류적분자궤제제공료기출。본문취체액조공신경원재조공수려선충고유면역방면전개토론，희망가이위고등생물신경면역간적조절궤제제공중요적사로화방법。
Caenorhabditis elegans would rapidly activate innate immunity once being infected with pathogens. Neuro-immune interactions which are through the nervous system to release such as neurotransmitters, neuropeptides and hormones to regulate the innate immune response. Those pathways include known dopamine signaling pathway, TGF-β signaling pathway and insulin signaling pathways. Recent studies show that NPR-1 neural circuits are also involved in the regulation of innate immunity and three neurons AQR, PQR and URX exposed to body fluid are under the regulation of NPR-1 neural circuits. Elegans nervous system has only 302 neurons and the structure is relatively simple and the npr-1 gene of elegans can encode GPCR which is similar to the mammalian neuropeptide Y (neuropeptideY, NPY) receptor, providing an edge for studying higher organisms on neuro-immune interactions. Research progress in relation to the field has been reviewed in present paper.