中国性科学
中國性科學
중국성과학
Chinese Journal of Human Sexuality
2015年
10期
14-16
,共3页
醋酸曲普瑞林%特发性中枢性早熟%治疗效果
醋痠麯普瑞林%特髮性中樞性早熟%治療效果
작산곡보서림%특발성중추성조숙%치료효과
Triptorelin acetate%Idiopathic central precocious puberty%Therapeutic effect
目的:探讨注射用醋酸曲普瑞林用于特发性中枢性早熟的治疗效果及安全性。方法:选取84例符合诊断标准且于我院进行治疗的特发性中枢性早熟患儿纳入研究,且采用随机、单盲法将其分作两组,对照组42例患儿给予醋酸甲地孕酮片,观察组42例患儿同时给予醋酸曲普瑞林,均连续治疗6个月,对其生长指标、性激素水平及不良反应情况进行比较。结果:两组患儿治疗前身高、体重、生长速度、预测身高及 BA /CA 比较差异均无统计学意义(P >0.05);而治疗后观察组患儿上述各项指标分别为(131.86±8.46)cm、(26.83±3.84)kg、(2.33±0.42)cm/半年、(161.89±2.99)cm 和(1.15±0.29),与本组治疗前和对照组治疗后进行比较差异均具有统计学意义(P <0.05)。两组患儿治疗前 LH、FSH 和 E2水平比较差异均无统计学意义(P >0.05),而观察组患儿治疗后上述各项指标分别为(1.89±0.43)IU /L、(2.34±0.34)IU /L、(11.29±3.02)pg/mL,与本组治疗前和对照组治疗后进行比较差异均具有统计学意义(P <0.05)。观察组未发现药物相关的不良反应,安全性较高。结论:注射用醋酸曲普瑞林用于特发性中枢性早熟疗效确切,能有降低患儿性激素水平,延缓其骨龄成熟,且不良反应少,临床应用价值高。
目的:探討註射用醋痠麯普瑞林用于特髮性中樞性早熟的治療效果及安全性。方法:選取84例符閤診斷標準且于我院進行治療的特髮性中樞性早熟患兒納入研究,且採用隨機、單盲法將其分作兩組,對照組42例患兒給予醋痠甲地孕酮片,觀察組42例患兒同時給予醋痠麯普瑞林,均連續治療6箇月,對其生長指標、性激素水平及不良反應情況進行比較。結果:兩組患兒治療前身高、體重、生長速度、預測身高及 BA /CA 比較差異均無統計學意義(P >0.05);而治療後觀察組患兒上述各項指標分彆為(131.86±8.46)cm、(26.83±3.84)kg、(2.33±0.42)cm/半年、(161.89±2.99)cm 和(1.15±0.29),與本組治療前和對照組治療後進行比較差異均具有統計學意義(P <0.05)。兩組患兒治療前 LH、FSH 和 E2水平比較差異均無統計學意義(P >0.05),而觀察組患兒治療後上述各項指標分彆為(1.89±0.43)IU /L、(2.34±0.34)IU /L、(11.29±3.02)pg/mL,與本組治療前和對照組治療後進行比較差異均具有統計學意義(P <0.05)。觀察組未髮現藥物相關的不良反應,安全性較高。結論:註射用醋痠麯普瑞林用于特髮性中樞性早熟療效確切,能有降低患兒性激素水平,延緩其骨齡成熟,且不良反應少,臨床應用價值高。
목적:탐토주사용작산곡보서림용우특발성중추성조숙적치료효과급안전성。방법:선취84례부합진단표준차우아원진행치료적특발성중추성조숙환인납입연구,차채용수궤、단맹법장기분작량조,대조조42례환인급여작산갑지잉동편,관찰조42례환인동시급여작산곡보서림,균련속치료6개월,대기생장지표、성격소수평급불량반응정황진행비교。결과:량조환인치료전신고、체중、생장속도、예측신고급 BA /CA 비교차이균무통계학의의(P >0.05);이치료후관찰조환인상술각항지표분별위(131.86±8.46)cm、(26.83±3.84)kg、(2.33±0.42)cm/반년、(161.89±2.99)cm 화(1.15±0.29),여본조치료전화대조조치료후진행비교차이균구유통계학의의(P <0.05)。량조환인치료전 LH、FSH 화 E2수평비교차이균무통계학의의(P >0.05),이관찰조환인치료후상술각항지표분별위(1.89±0.43)IU /L、(2.34±0.34)IU /L、(11.29±3.02)pg/mL,여본조치료전화대조조치료후진행비교차이균구유통계학의의(P <0.05)。관찰조미발현약물상관적불량반응,안전성교고。결론:주사용작산곡보서림용우특발성중추성조숙료효학절,능유강저환인성격소수평,연완기골령성숙,차불량반응소,림상응용개치고。
Objectives:To investigate the curative effect and safety of injection of triptorelin acetate in treatment of idiopathic central precocious puberty.Methods:84 children with idiopathic central precocious puberty in our hospital were included in the study and divided into two groups randomly.According to the single blind meth-od,42 cases in the control group were given megestrol acetate tablets,while 42 cases in the observation group were given triptorelin acetate in the meantime,for continuous treatment of 6 months.The growth index,sex hormone lev-els and adverse reaction of the two groups were compared.Results:The body weight,height growth rate,predicted height and BA /CA of the two groups before treatment were not significant difference (P >0.05);and after the treat-ment,the above indexes in the observation group were (1 31 .86 ±8.46)cm,(26.83 ±3.84)kg,(2.33 ±0.42) cm/half year,(1 61 .89 ±2.99)cm and (1 .1 5 +0.29).Compared with these before the treatment and the inde-xes of control groups after treatment,the differences were significant (P <0.05).LH,FSH and E2 levels in the two groups before treatment were not significantly different (P >0.05).The above indexes in the observation group after treatment were (1 .89 ±0.43)IU /L,(2.34 ±0.34)IU /L,(1 1 .29 ±3.02)pg/mL.Compared with the indexes of the observation group before treatment and the indexes of control group after treatment,the differences were statis-tically significant (P <0.05).There was no drug related adverse reaction in the observation group,which was of high security.Conclusion:The injection of triptorelin acetate for idiopathic central precocious puberty in children has a definite curative effect,which can reduce the level of sex hormone,delay the maturation of bone age,with less adverse reaction,and a high clinical application value.