CAJ | 학술논문

目的：比较评价阴茎皮片／口腔黏膜移植物尿道成形术治疗尿道狭窄优劣。方法：利用数据库 Medline，EMbase，Cochrane library，Web of Science，Scopus 和中国生物医学文献数据库，检索关于阴茎皮片／口腔黏膜移植物尿道成形术治疗尿道狭窄临床研究文章，提取资料，应用 State12．0进行 Meta 分析。结果：纳入10个非随机对照研究和1个随机对照试验，共699人。唯一的随机对照试验显示，口腔黏膜组与阴茎皮片组成功率差别无统计学意义（90．5％ vs 87．5％，P ＝0．07）。非随机对照研究 Meta 分析表明，口腔黏膜组优于阴茎皮片组（RR ＝0．86，95％CI 0．77－0．96，P ＝0．008）。按手术方式亚组分析表明，采用背侧镶嵌尿道成形术，口腔黏膜与阴茎皮片效果相当（RR ＝0．90，95％ CI：0．77－1．06）。结论：阴茎皮片移植物与口腔黏膜游离移植物在前尿道狭窄一期背侧镶嵌成形术中效果相当，皆可选择。但此结论仍需大样本随机对照试验进一步证实。
목적：비교평개음경피편／구강점막이식물뇨도성형술치료뇨도협착우렬。방법：이용수거고 Medline，EMbase，Cochrane library，Web of Science，Scopus 화중국생물의학문헌수거고，검색관우음경피편／구강점막이식물뇨도성형술치료뇨도협착림상연구문장，제취자료，응용 State12．0진행 Meta 분석。결과：납입10개비수궤대조연구화1개수궤대조시험，공699인。유일적수궤대조시험현시，구강점막조여음경피편조성공솔차별무통계학의의（90．5％ vs 87．5％，P ＝0．07）。비수궤대조연구 Meta 분석표명，구강점막조우우음경피편조（RR ＝0．86，95％CI 0．77－0．96，P ＝0．008）。안수술방식아조분석표명，채용배측양감뇨도성형술，구강점막여음경피편효과상당（RR ＝0．90，95％ CI：0．77－1．06）。결론：음경피편이식물여구강점막유리이식물재전뇨도협착일기배측양감성형술중효과상당，개가선택。단차결론잉수대양본수궤대조시험진일보증실。
Objectives:To compare and assess the efficacy of penile skin graft (PSG)/buccal mucosa graft (BMG)urethroplasty in the treatment of urethral stricture.Methods:Related papers on the use of PSG/BMG ure-throplasty in the reconstruction of urethral defect associated with urethral stricture were searched via Medline,EM-base,Cochrane library,Web of Science,Scopus and CBMDISC.The data extracted from eligible studies were pooled using Stata 1 2.0 software.Results:A total of 1 1 studies,including 1 0 non -randomized studies and a ran-domized controlled trial,involving 699 patients,were included.The randomized controlled trial demonstrated that success rate of BMG was 90.5% versus 87.5% of PSG (P =0.07).Meta -analysis of non -randomized studies showed overall success rate of urethroplasty with BMG was better than PSG (RR =0.86,95%CI 0.77 -0.96,P =0.008).Subgroup analysis by surgery indicated dorsal -onlay urethroplasty with PSG or BMG had a similar overall success rate (RR =0.90,95% CI:0.77 -1 .06).Conclusion:One -stage dorsal -onlay urethroplasty with PSG or BMG has a comparable success rate in the treatment of anterior urethral stricture.Additional high -quality and large -scale randomized controlled trials are warranted to further validate these conclusions.