中国性科学
中國性科學
중국성과학
Chinese Journal of Human Sexuality
2015年
10期
5-8
,共4页
瘦素%白细胞介素 -8%子宫内膜异位
瘦素%白細胞介素 -8%子宮內膜異位
수소%백세포개소 -8%자궁내막이위
Leptin%Interleukin -8%Endometriosis
目的:探讨子宫内膜异位(EMT)患者腹腔液中瘦素及白介素-8(IL -8)的表达差异及其与 EMT 进展的相关关系。方法:选取53例 EMT 患者(EMT 组)及45例对照组患者,采集其腹腔液并通过酶联免疫吸附法(ELISA)对瘦素及 IL -8表达水平进行测定,分析两组患者表达水平差异及其与 EMT 患者rAFS 分期、疼痛评分的相关性。结果:EMT 组患者相较对照组患者出现瘦素及 IL -8表达水平的升高,并且差异具有统计学意义(均 P <0.001)。早期 EMT 患者瘦素表达水平相较晚期 EMT 组明显升高(P <0.001),而 IL -8表达水平则明显降低(P <0.001)。卵巢巧克力囊肿组患者瘦素表达水平明显低于盆腔EMT 组(4.8±1.7ng/L vs.9.3±2.5ng/L,P <0.001),但两组患者腹腔液 IL -8表达水平差异则不具有统计学意义(P =0.651)。Pearson 相关分析表明,瘦素表达水平与患者 rAFS 呈现负相关关系(r =-0.5731,P <0.05)而与 EMT 患者疼痛评分不具有相关关系(r =0.0036,P >0.05)。IL -8表达水平与患者 rAFS 呈现正相关关系(r =0.6148,P <0.05)而与晚期 EMT 患者的疼痛评分具有显著的正相关关系(r =0.6391,P <0.05)。结论:EMT 患者腹腔液出现瘦素及 IL -8的异常增高并且其与 EMT 的进展及临床症状具有一定相关性,值得在临床上对其进行关注。
目的:探討子宮內膜異位(EMT)患者腹腔液中瘦素及白介素-8(IL -8)的錶達差異及其與 EMT 進展的相關關繫。方法:選取53例 EMT 患者(EMT 組)及45例對照組患者,採集其腹腔液併通過酶聯免疫吸附法(ELISA)對瘦素及 IL -8錶達水平進行測定,分析兩組患者錶達水平差異及其與 EMT 患者rAFS 分期、疼痛評分的相關性。結果:EMT 組患者相較對照組患者齣現瘦素及 IL -8錶達水平的升高,併且差異具有統計學意義(均 P <0.001)。早期 EMT 患者瘦素錶達水平相較晚期 EMT 組明顯升高(P <0.001),而 IL -8錶達水平則明顯降低(P <0.001)。卵巢巧剋力囊腫組患者瘦素錶達水平明顯低于盆腔EMT 組(4.8±1.7ng/L vs.9.3±2.5ng/L,P <0.001),但兩組患者腹腔液 IL -8錶達水平差異則不具有統計學意義(P =0.651)。Pearson 相關分析錶明,瘦素錶達水平與患者 rAFS 呈現負相關關繫(r =-0.5731,P <0.05)而與 EMT 患者疼痛評分不具有相關關繫(r =0.0036,P >0.05)。IL -8錶達水平與患者 rAFS 呈現正相關關繫(r =0.6148,P <0.05)而與晚期 EMT 患者的疼痛評分具有顯著的正相關關繫(r =0.6391,P <0.05)。結論:EMT 患者腹腔液齣現瘦素及 IL -8的異常增高併且其與 EMT 的進展及臨床癥狀具有一定相關性,值得在臨床上對其進行關註。
목적:탐토자궁내막이위(EMT)환자복강액중수소급백개소-8(IL -8)적표체차이급기여 EMT 진전적상관관계。방법:선취53례 EMT 환자(EMT 조)급45례대조조환자,채집기복강액병통과매련면역흡부법(ELISA)대수소급 IL -8표체수평진행측정,분석량조환자표체수평차이급기여 EMT 환자rAFS 분기、동통평분적상관성。결과:EMT 조환자상교대조조환자출현수소급 IL -8표체수평적승고,병차차이구유통계학의의(균 P <0.001)。조기 EMT 환자수소표체수평상교만기 EMT 조명현승고(P <0.001),이 IL -8표체수평칙명현강저(P <0.001)。란소교극력낭종조환자수소표체수평명현저우분강EMT 조(4.8±1.7ng/L vs.9.3±2.5ng/L,P <0.001),단량조환자복강액 IL -8표체수평차이칙불구유통계학의의(P =0.651)。Pearson 상관분석표명,수소표체수평여환자 rAFS 정현부상관관계(r =-0.5731,P <0.05)이여 EMT 환자동통평분불구유상관관계(r =0.0036,P >0.05)。IL -8표체수평여환자 rAFS 정현정상관관계(r =0.6148,P <0.05)이여만기 EMT 환자적동통평분구유현저적정상관관계(r =0.6391,P <0.05)。결론:EMT 환자복강액출현수소급 IL -8적이상증고병차기여 EMT 적진전급림상증상구유일정상관성,치득재림상상대기진행관주。
Objectives:To explore the expression difference of leptin and interleukin -8 (IL -8)in peri-toneal fluid and their correlation with the progression of endometriosis (EMT).Methods:53 patients with EMT (EMT group)and 45 otherwise patients were selected and the peritoneal fluid was collected to detect the expression level of leptin and IL -8 using the ELISA.The expression level of leptin and IL -8 were compared between the two groups and their correlation with rAFS stage and pain scores were analyzed.Results:Level of leptin and IL -8 in EMT group increased compared with the control group (P <0.001 ).Significantly higher level of leptin and lower level of IL -8 were demonstrated in patients of EMT early stage than that of advanced stage (both P <0.001 ).Lev-el of leptin in patients with single chocolate cyst of ovary significantly decreased (4.8 ±1 .7ng/L vs.9.3 ±2.5ng/L,P <0.001 )compared with those with single pelvic EMT,but difference in the IL -8 expression is not statistical-ly significant (P =0.651 ).Pearson correlation analysis showed that expression level of leptin correlated negatively with rAFS stage of patients (r =-0.5731 ,P <0.05)and not correlated with patients’pain scores (r =0.0036,P>0.05).Expression level of IL -8 correlated positively with rAFS stage of patients with EMT (r =0.61 48,P <0.05)and with pain scores in patients with advanced EMT (r =0.6391 ,P <0.05).Conclusion:Expression lev-els of leptin and IL -8 increase in peritoneal fluid in patients with EMT and correlates with the progression of EMT and clinical symptoms,which is worth more attention in clinical practice.