中国医药导刊
中國醫藥導刊
중국의약도간
Chinese Journal of Medical Guide
2015年
9期
953-954,956
,共3页
布比卡因%微球%局麻药%缓释制剂%药效学
佈比卡因%微毬%跼痳藥%緩釋製劑%藥效學
포비잡인%미구%국마약%완석제제%약효학
Bupivacaine%Microspheres%Local anesthetic%Sustained release preparations%Pharmacodynamics
目的:研究布比卡因微球对大鼠的局麻作用.方法:取18只Wister大鼠随机分为生理盐水组、阳性对照组和微球组,分别注射生理盐水、0.75%盐酸布比卡因注射剂和布比卡因微球,通过热板实验考察药物对大鼠的局麻作用并进行分析.结果:布比卡因微球能显著延长大鼠运动与感觉阻滞的持续效应.结论:布比卡因微球对于大鼠的局部麻醉表现出明显缓释作用.
目的:研究佈比卡因微毬對大鼠的跼痳作用.方法:取18隻Wister大鼠隨機分為生理鹽水組、暘性對照組和微毬組,分彆註射生理鹽水、0.75%鹽痠佈比卡因註射劑和佈比卡因微毬,通過熱闆實驗攷察藥物對大鼠的跼痳作用併進行分析.結果:佈比卡因微毬能顯著延長大鼠運動與感覺阻滯的持續效應.結論:佈比卡因微毬對于大鼠的跼部痳醉錶現齣明顯緩釋作用.
목적:연구포비잡인미구대대서적국마작용.방법:취18지Wister대서수궤분위생리염수조、양성대조조화미구조,분별주사생리염수、0.75%염산포비잡인주사제화포비잡인미구,통과열판실험고찰약물대대서적국마작용병진행분석.결과:포비잡인미구능현저연장대서운동여감각조체적지속효응.결론:포비잡인미구대우대서적국부마취표현출명현완석작용.
Objective: To evaluate the local anesthetic effects of bupivacaine microspheres(BUP-MS) on rats.Methods:18 Wister rats were randomly divided into three groups and injected with saline, 0.75% bupivacaine hydrochloride injection and BUP-MS respectively. The local anesthetic effects were investigated through rats' hot - plate test.Results:The action of BUP-MS could be prolonged for rats' sensory block and motor block significantly.Conclusion:BUP-MS have significant sustained- release characteristics on rats.
