CAJ | 학술논문

目的:探讨右美托咪定对急性颅脑损伤开颅手术患者的脑保护作用.方法:选择68例急性颅脑损伤开颅手术患者,随机分为A组和B组各34例,全麻下行开颅手术,A组麻醉诱导前10min内缓慢静注右美托咪定1μg/kg,维持采用静脉连续输注0.5μg/kg?h至术毕,B组相同方式给予等量生理盐水.观察不同时点血清S-100β、NSE、IL-6、TNF-α水平及颅内压.结果:A组和B组T0-T3血清S-100β、NSE水平、血清IL-6、TNF-α水平呈上升趋势(P<0.05),A组T1-T3明显低于B组(P<0.05).A、B组颅内压T1之后均显著下降(P<0.05),T3B组明显回升(P<0.05),且明显高于A组(P<0.05).结论:右美托咪定可抑制急性颅脑损伤开颅手术患者炎症反应,具有一定的脑保护作用.
목적:탐토우미탁미정대급성로뇌손상개로수술환자적뇌보호작용.방법:선택68례급성로뇌손상개로수술환자,수궤분위A조화B조각34례,전마하행개로수술,A조마취유도전10min내완만정주우미탁미정1μg/kg,유지채용정맥련속수주0.5μg/kg?h지술필,B조상동방식급여등량생리염수.관찰불동시점혈청S-100β、NSE、IL-6、TNF-α수평급로내압.결과:A조화B조T0-T3혈청S-100β、NSE수평、혈청IL-6、TNF-α수평정상승추세(P<0.05),A조T1-T3명현저우B조(P<0.05).A、B조로내압T1지후균현저하강(P<0.05),T3B조명현회승(P<0.05),차명현고우A조(P<0.05).결론:우미탁미정가억제급성로뇌손상개로수술환자염증반응,구유일정적뇌보호작용.
Objective: To study the protective effect of dexmedetomidine in treatment of patients with acute craniocerebral traum craniotomy.Methods:68 patients with acute brain injury craniotomy surgery patients were randomly divided into group A and group B,34 patients under general anesthesia craniotomy,A group 10min intravenous dexmedetomidine given 1μg/kg before induction of anesthesia After intravenous pump infusion of 0.5μg/kg?h to surgery, the same way as group B given normal saline.Observed four different time serum S-100β, NSE, IL-6, TNF-α levels and intracranial pressure.Results:A group and group B T0-T3 serum S-100β,NSE level,serum IL-6,TNF-α level rise(P<0.05),A group T1-T3 serum S-100β,NSE,IL-6,TNF-α levels were significantly lower than in group B(P<0.05). After the group A and group B T1 intracranial pressure were significantly decreased (P<0.05),T3B intracranial pressure group rebounded significantly(P<0.05),higher than group A(P<0.05).Conclusion:Dexmedetomidine suppressed patients with acute brain injury craniotomy inflammation,has a neuroprotective effect.