中华眼科杂志
中華眼科雜誌
중화안과잡지
Chinese Journal of Ophthalmology
2015年
10期
746-749
,共4页
周婉瑜%杨治坤%刘新书%韩筱煦%张美芬
週婉瑜%楊治坤%劉新書%韓篠煦%張美芬
주완유%양치곤%류신서%한소후%장미분
贝赫切特综合征%葡萄膜炎%中央凹%视敏度%体层摄影术,光学相干
貝赫切特綜閤徵%葡萄膜炎%中央凹%視敏度%體層攝影術,光學相榦
패혁절특종합정%포도막염%중앙요%시민도%체층섭영술,광학상간
Behcet syndrome%Uveitis%Fovea centralis%Visual acuity%Tomography,optical coherence
目的 分析Behcet病患者葡萄膜炎缓解期的黄斑中心凹结构与最佳矫正视力(BCVA)的关系.方法 回顾性系列病例研究.对2012年1月至2015年1月在北京协和医院眼科随诊的Behcet病葡萄膜炎缓解期患者51例(79只眼)的临床资料进行回顾性分析.其中男性40例,女性11例,年龄18 ～46岁,平均(31.5±6.9)岁.所有患者经过完整的眼部检查,包括BCVA、眼压、裂隙灯显微镜检查、眼底镜和频域OCT.按照黄斑中心凹厚度(CMT)及椭圆体形态将所有患眼分组,CMT厚组:CMT≥130 μm,CMT薄组:CMT＜130 μm.进一步按照CMT厚度及椭圆体形态综合情况将所有患眼分为4组:第1组:CMT厚且椭圆体层(+);第2组:CMT厚且椭圆体层(-);第3组:CMT薄且椭圆体层(+);第4组:CMT薄且椭圆体层(-).应用Kruskal Wallis检验比较多组间视力差异,Mann-Whitney U检验比较两组间视力差异,必要时行Bonferroni校正.结果 51例(79只眼)Behcet病葡萄膜炎缓解期患者的CMT平均为(151.4±62.3) μrn,其中43只眼CMT≥130 μm,36只眼CMT＜130 μm;在CMT≥130 μm眼中椭圆体层(+)32只眼,椭圆体层(-)11只眼;CMT＜130 μm眼中椭圆体层(+)2只眼,椭圆体层(-)34只眼.结果表明,CMT≥130 μm组BCVA好于CMT＜ 130 μm组(logMAR0.1和logMAR1.0),差异有统计学意义(z=-6.88, P＜0.01).椭圆体层(+)组BCVA好于椭圆体层(-)组(logMAR0.1和logMAR1.0),差异有统计学意义(z=-6.60,P＜0.01).结论 CMT及椭圆体层完整的Behcet病葡萄膜炎患者其BCVA相对更好.
目的 分析Behcet病患者葡萄膜炎緩解期的黃斑中心凹結構與最佳矯正視力(BCVA)的關繫.方法 迴顧性繫列病例研究.對2012年1月至2015年1月在北京協和醫院眼科隨診的Behcet病葡萄膜炎緩解期患者51例(79隻眼)的臨床資料進行迴顧性分析.其中男性40例,女性11例,年齡18 ～46歲,平均(31.5±6.9)歲.所有患者經過完整的眼部檢查,包括BCVA、眼壓、裂隙燈顯微鏡檢查、眼底鏡和頻域OCT.按照黃斑中心凹厚度(CMT)及橢圓體形態將所有患眼分組,CMT厚組:CMT≥130 μm,CMT薄組:CMT＜130 μm.進一步按照CMT厚度及橢圓體形態綜閤情況將所有患眼分為4組:第1組:CMT厚且橢圓體層(+);第2組:CMT厚且橢圓體層(-);第3組:CMT薄且橢圓體層(+);第4組:CMT薄且橢圓體層(-).應用Kruskal Wallis檢驗比較多組間視力差異,Mann-Whitney U檢驗比較兩組間視力差異,必要時行Bonferroni校正.結果 51例(79隻眼)Behcet病葡萄膜炎緩解期患者的CMT平均為(151.4±62.3) μrn,其中43隻眼CMT≥130 μm,36隻眼CMT＜130 μm;在CMT≥130 μm眼中橢圓體層(+)32隻眼,橢圓體層(-)11隻眼;CMT＜130 μm眼中橢圓體層(+)2隻眼,橢圓體層(-)34隻眼.結果錶明,CMT≥130 μm組BCVA好于CMT＜ 130 μm組(logMAR0.1和logMAR1.0),差異有統計學意義(z=-6.88, P＜0.01).橢圓體層(+)組BCVA好于橢圓體層(-)組(logMAR0.1和logMAR1.0),差異有統計學意義(z=-6.60,P＜0.01).結論 CMT及橢圓體層完整的Behcet病葡萄膜炎患者其BCVA相對更好.
목적 분석Behcet병환자포도막염완해기적황반중심요결구여최가교정시력(BCVA)적관계.방법 회고성계렬병례연구.대2012년1월지2015년1월재북경협화의원안과수진적Behcet병포도막염완해기환자51례(79지안)적림상자료진행회고성분석.기중남성40례,녀성11례,년령18 ～46세,평균(31.5±6.9)세.소유환자경과완정적안부검사,포괄BCVA、안압、렬극등현미경검사、안저경화빈역OCT.안조황반중심요후도(CMT)급타원체형태장소유환안분조,CMT후조:CMT≥130 μm,CMT박조:CMT＜130 μm.진일보안조CMT후도급타원체형태종합정황장소유환안분위4조:제1조:CMT후차타원체층(+);제2조:CMT후차타원체층(-);제3조:CMT박차타원체층(+);제4조:CMT박차타원체층(-).응용Kruskal Wallis검험비교다조간시력차이,Mann-Whitney U검험비교량조간시력차이,필요시행Bonferroni교정.결과 51례(79지안)Behcet병포도막염완해기환자적CMT평균위(151.4±62.3) μrn,기중43지안CMT≥130 μm,36지안CMT＜130 μm;재CMT≥130 μm안중타원체층(+)32지안,타원체층(-)11지안;CMT＜130 μm안중타원체층(+)2지안,타원체층(-)34지안.결과표명,CMT≥130 μm조BCVA호우CMT＜ 130 μm조(logMAR0.1화logMAR1.0),차이유통계학의의(z=-6.88, P＜0.01).타원체층(+)조BCVA호우타원체층(-)조(logMAR0.1화logMAR1.0),차이유통계학의의(z=-6.60,P＜0.01).결론 CMT급타원체층완정적Behcet병포도막염환자기BCVA상대경호.
Objective To study the relationship between the structure of macular central fovea and the best-corrected visual acuity (BCVA) during remission stage of Behcet's disease associated uveitis.Methods Retrospective case series studies.The study covered 5 1 patients (79 eyes) during remission stage of Behcet's disease-associated uveitis from Peking Union Medical College Hospital in a three-year period from January 2012 to January 2015.There were 40 males, 11 females with the average age of 31.5±6.9 years old (ranging from 18 to 46).All the patients received a complete set of ophthalmic examination, including BCVA, intraocular pressure, slit-lamp microscope, ophthalmoscope and frequency domain optical coherence tomography (OCT).All the eyes were divided into 4 groups according to central macular thickness (CMT) (the thick CMT group: CMT≥130 μm;the thin CMT group: CMT＜130 μm) and the existence of ellipsoid zone.Group 1: thick CMT and ellipsoid (+);Group 2: thick CMT and ellipsoid (-);Group 3: thin CMT and ellipsoid (+);Group 4: thin CMT and ellipsoid (-).Sight disparity among multiple groups was tested with Kruskal Wallis, while the difference between two groups was tested with Mann-Whitney U test.Bonferroni correction was conducted when necessary.Results The mean CMT was (151.4±62.3)μm in all eyes (43 eyes in thick CMT group, 36 eyes in thin CMT group).According to grouping rule, there were 32 eyes in group 1, 11 eyes in group 2, 2 eyes in group 3 and 34 eyes in group 4.The BCVA of thick CMT group was better than that of thin CMT group (logMAR0.1 and logMAR1.0) (z=-6.88, P＜0.O1).In addition, the BCVA of ellipsoid (+) group was better than the ellipsoid (-) group.(log MAR0.1 and log MAR1.0) (z=-6.60, P＜ 0.01).Conclusion Thick CMT and intact ellipsoid zone usually associated with relatively better BCVA in Behcet's disease-associated uveitis patients.
