医药前沿
醫藥前沿
의약전연
Yiayao Qianyan
2015年
27期
20-22
,共3页
西宁地区%卒中后抑郁%血清hs-CRP%血清Hcy
西寧地區%卒中後抑鬱%血清hs-CRP%血清Hcy
서저지구%졸중후억욱%혈청hs-CRP%혈청Hcy
Xining area%Depression after stroke%The hs-CRP serum%Serum Hcy
目的:观察西宁地区中青年脑卒中患者急性期卒中后抑郁(poststroke depression,PSD)发生情况及与血清hs-CRP、Hcy关系.方法:收集世居西宁地区124例中青年动脉粥样硬化性脑梗死汉族患者,根据目前脑血管病指南治疗,登记所有患者入院时人口学资料、既往病史、有关临床资料, 入院后及发病15天给予血清hs-CRP、Hcy化验.入院后及发病15天进行汉密尔顿抑郁量表评分(HAMD评分)评定, 通过参考《美国精神障碍诊断与统计手册(第4版)》(DSM-Ⅳ)躯体疾病所致心境障碍(293.83)的标准,将患者分为PSD组和非PSD组,计算西宁地区中青年卒中急性期抑郁的发生率、比较两组血清hs-CRP、Hcy水平.结果:西宁地区中青年动脉粥样硬化性脑梗死患者发病15天时PSD的发生率为34.68%,女性发生率高于男性,差异有统计学意义(P<0.05).PSD组入院时血清hs-CRP、Hcy水平与非PSD组比较,差异无统计学意义(P>0.05),发病15天血清hs-CRP、Hcy水平高于非PSD组,差异具有统计学意义(P<0.05).结论:西宁地区中青年动脉粥样硬化性脑梗死患者急性期抑郁发生率较高,女性较男性高发,卒中后抑郁发生与血清hs-CRP、Hcy水平增高有关.
目的:觀察西寧地區中青年腦卒中患者急性期卒中後抑鬱(poststroke depression,PSD)髮生情況及與血清hs-CRP、Hcy關繫.方法:收集世居西寧地區124例中青年動脈粥樣硬化性腦梗死漢族患者,根據目前腦血管病指南治療,登記所有患者入院時人口學資料、既往病史、有關臨床資料, 入院後及髮病15天給予血清hs-CRP、Hcy化驗.入院後及髮病15天進行漢密爾頓抑鬱量錶評分(HAMD評分)評定, 通過參攷《美國精神障礙診斷與統計手冊(第4版)》(DSM-Ⅳ)軀體疾病所緻心境障礙(293.83)的標準,將患者分為PSD組和非PSD組,計算西寧地區中青年卒中急性期抑鬱的髮生率、比較兩組血清hs-CRP、Hcy水平.結果:西寧地區中青年動脈粥樣硬化性腦梗死患者髮病15天時PSD的髮生率為34.68%,女性髮生率高于男性,差異有統計學意義(P<0.05).PSD組入院時血清hs-CRP、Hcy水平與非PSD組比較,差異無統計學意義(P>0.05),髮病15天血清hs-CRP、Hcy水平高于非PSD組,差異具有統計學意義(P<0.05).結論:西寧地區中青年動脈粥樣硬化性腦梗死患者急性期抑鬱髮生率較高,女性較男性高髮,卒中後抑鬱髮生與血清hs-CRP、Hcy水平增高有關.
목적:관찰서저지구중청년뇌졸중환자급성기졸중후억욱(poststroke depression,PSD)발생정황급여혈청hs-CRP、Hcy관계.방법:수집세거서저지구124례중청년동맥죽양경화성뇌경사한족환자,근거목전뇌혈관병지남치료,등기소유환자입원시인구학자료、기왕병사、유관림상자료, 입원후급발병15천급여혈청hs-CRP、Hcy화험.입원후급발병15천진행한밀이돈억욱량표평분(HAMD평분)평정, 통과삼고《미국정신장애진단여통계수책(제4판)》(DSM-Ⅳ)구체질병소치심경장애(293.83)적표준,장환자분위PSD조화비PSD조,계산서저지구중청년졸중급성기억욱적발생솔、비교량조혈청hs-CRP、Hcy수평.결과:서저지구중청년동맥죽양경화성뇌경사환자발병15천시PSD적발생솔위34.68%,녀성발생솔고우남성,차이유통계학의의(P<0.05).PSD조입원시혈청hs-CRP、Hcy수평여비PSD조비교,차이무통계학의의(P>0.05),발병15천혈청hs-CRP、Hcy수평고우비PSD조,차이구유통계학의의(P<0.05).결론:서저지구중청년동맥죽양경화성뇌경사환자급성기억욱발생솔교고,녀성교남성고발,졸중후억욱발생여혈청hs-CRP、Hcy수평증고유관.
Objective Observe the xining region young depression after acute stroke patients with cerebral apoplexy (poststroke',PSD) occurrence and the relationship between serum hs-CRP, Hcy.Methods Collecting 124 cases of young and middle-aged patients with atherosclerotic cerebral infarction, registration of all patients admitted to hospital with demographic data, medical history, etc. Divided the patients into the PSD and the PSD group, compared two groups of serum hs CRP, Hcy levels.Results Xining in young and middle-aged patients with atherosclerotic cerebral infarction incidence 15 days the incidence rate of PSD was 34.68%, incidence of women more than men, the difference was statistically significant (P<0.05). PSD group hs-CRP serum on admission, Hcy levels compared with the PSD group, there was no statistically significant difference (P>0.05), 15 days the hs-CRP serum, Hcy levels higher than that of the PSD group, difference has statistical significance (P<0.05).Conclusions The atherosclerotic process in the xining region of middle-aged and young patients with cerebral infarction were higher in the acute phase of depression, a high incidence of women than men, poststroke depression occur are associated with increased serum hs-CRP, Hcy levels.
