医药前沿
醫藥前沿
의약전연
Yiayao Qianyan
2015年
27期
37-38
,共2页
结肠炎%葡聚糖硫酸钠%人参皂苷
結腸炎%葡聚糖硫痠鈉%人參皂苷
결장염%포취당류산납%인삼조감
Colitis%Dextran sulfate sodium%Ginsenoside
目的:研究人参皂苷对葡聚糖硫酸钠(DSS)诱导的小鼠结肠炎的防治作用.方法:健康昆明种小鼠,随机分为正常组N、模型组M、人参皂苷组G,建立葡聚糖硫酸钠(DSS)诱导的小鼠结肠炎模型.正常组、模型组用0.9%氯化钠溶液灌胃,人参皂苷组用人参皂苷溶液灌胃.结果:与模型组相比,人参皂苷组小鼠结肠炎疾病活动度指数DAI评分和结肠粘膜组织学损伤评分(CMDI)明显下降(P<0.05).结论:人参皂苷可减轻由DSS诱导的小鼠结肠炎的炎症症状.
目的:研究人參皂苷對葡聚糖硫痠鈉(DSS)誘導的小鼠結腸炎的防治作用.方法:健康昆明種小鼠,隨機分為正常組N、模型組M、人參皂苷組G,建立葡聚糖硫痠鈉(DSS)誘導的小鼠結腸炎模型.正常組、模型組用0.9%氯化鈉溶液灌胃,人參皂苷組用人參皂苷溶液灌胃.結果:與模型組相比,人參皂苷組小鼠結腸炎疾病活動度指數DAI評分和結腸粘膜組織學損傷評分(CMDI)明顯下降(P<0.05).結論:人參皂苷可減輕由DSS誘導的小鼠結腸炎的炎癥癥狀.
목적:연구인삼조감대포취당류산납(DSS)유도적소서결장염적방치작용.방법:건강곤명충소서,수궤분위정상조N、모형조M、인삼조감조G,건립포취당류산납(DSS)유도적소서결장염모형.정상조、모형조용0.9%록화납용액관위,인삼조감조용인삼조감용액관위.결과:여모형조상비,인삼조감조소서결장염질병활동도지수DAI평분화결장점막조직학손상평분(CMDI)명현하강(P<0.05).결론:인삼조감가감경유DSS유도적소서결장염적염증증상.
Objective To study the preventive and therapeutic effect of Ginsenoside on the colitis induced by Dextran sulfate sodium(DSS) in mice.Methods Healthy Kunming mice were randomly divided into normal group N, model group M and ginsenoside group G. The colitis induced by Dextran sulfate sodium(DSS) was established in mice.The normal group and the model group were treated with 0.9% sodium chloride solution, and the ginsenoside group was irrigated with the ginsenoside solution.Results Compared with the model group, Disease Activity Index(DAI)and Colon Mucosal Damage Index(CMDI were significantly decreased (P<0.05). Conclusion Ginsenoside can reduce the inflammatory symptoms of the colitis induced by DSS in mice.
