CAJ | 학술논문

[目的]探讨阿司匹林联合丹蛭降糖胶囊对“气阴两虚夹瘀”型高血压及高血压合并2型糖尿病患者血小板聚集率(platelet aggregation rate， PAG)和凝血功能的影响。[方法]按照就诊顺序及病史选取50例“气阴两虚夹瘀”型单纯高血压患者为A组，50例“气阴两虚夹瘀”型高血压合并2型糖尿病患者为B组，均已常规服用阿司匹林(100 mg，1次/d)＞2周，入选后两组均加用丹蛭降糖胶囊3粒，3次/d，连服4周。于治疗前后检测血小板计数（blood platelet count，BPC）、PAG、凝血全套等。[结果]①血小板计数：两组治疗前后血小板计数均无明显差异(P>0.05)。治疗前后两组间的血小板计数均无明显差异(P>0.05)。②PAG：两组患者治疗后花生四烯酸（arachidonic acid，AA）诱导的PAG均明显低于治疗前(P<0.05)。两组间比较，治疗前B组PAG较A组高，差异有统计学意义(P<0.05)；治疗后两组PAG的差异无统计学意义(P>0.05)。③凝血功能：两组患者治疗后D-二聚体、血浆纤维蛋白原（plasma fibrinogen，FIB）及部分凝血活酶时间（activated partial thromboplastin time，APTT）较治疗前均有明显改善(P<0.05)；凝血酶时间（thrombin time，TT）及凝血酶原时间(prothrombin time，PT)两组治疗前后均无明显改善(P>0.05)。两组间比较，治疗前两组D-二聚体及凝血四项无显著差异(P>0.05)；治疗后B组FIB下降值较A组明显(P<0.05)，APTT及D-二聚体下降值两组无明显差异(P>0.05)。[结论]较单独应用阿司匹林治疗，联合丹蛭降糖胶囊可以进一步降低两组患者PAG水平、改善凝血功能，对于合并糖尿病患者在降低血浆D-二聚体、FIB及APTT水平更明显。
[목적]탐토아사필림연합단질강당효낭대“기음량허협어”형고혈압급고혈압합병2형당뇨병환자혈소판취집솔(platelet aggregation rate， PAG)화응혈공능적영향。[방법]안조취진순서급병사선취50례“기음량허협어”형단순고혈압환자위A조，50례“기음량허협어”형고혈압합병2형당뇨병환자위B조，균이상규복용아사필림(100 mg，1차/d)＞2주，입선후량조균가용단질강당효낭3립，3차/d，련복4주。우치료전후검측혈소판계수（blood platelet count，BPC）、PAG、응혈전투등。[결과]①혈소판계수：량조치료전후혈소판계수균무명현차이(P>0.05)。치료전후량조간적혈소판계수균무명현차이(P>0.05)。②PAG：량조환자치료후화생사희산（arachidonic acid，AA）유도적PAG균명현저우치료전(P<0.05)。량조간비교，치료전B조PAG교A조고，차이유통계학의의(P<0.05)；치료후량조PAG적차이무통계학의의(P>0.05)。③응혈공능：량조환자치료후D-이취체、혈장섬유단백원（plasma fibrinogen，FIB）급부분응혈활매시간（activated partial thromboplastin time，APTT）교치료전균유명현개선(P<0.05)；응혈매시간（thrombin time，TT）급응혈매원시간(prothrombin time，PT)량조치료전후균무명현개선(P>0.05)。량조간비교，치료전량조D-이취체급응혈사항무현저차이(P>0.05)；치료후B조FIB하강치교A조명현(P<0.05)，APTT급D-이취체하강치량조무명현차이(P>0.05)。[결론]교단독응용아사필림치료，연합단질강당효낭가이진일보강저량조환자PAG수평、개선응혈공능，대우합병당뇨병환자재강저혈장D-이취체、FIB급APTT수평경명현。
Objective] Study effect of the aspirin joined with Dan vermiculite hypoglycemic capsule on platelet aggregation rate and blood coagulation function in patients with hypertension and hypertension combined with type 2 diabetes mellitus . [Methods] According to the history of medical order, select 50 patients of group A, patients with high blood pressure so as to 50 patients with hypertension combined with type 2 diabetes mellitus as group B, the doctor of traditional Chinese medicine syndrome differentiation is"qi and Yin deficiency clip stasis"type, have regular aspirin(100 mg, 1/d)>2 weeks, to be included in the two groups after all with Dan vermiculite hypoglycemic capsule 3 grains, three times a day, take 4 weeks, in the detection of platelet count(BPC) before and after the treatment, platelet aggregation rate(PAG), coagulation full set, etc. [Results] 1. The platelet count, platelet count before and after treatment, two groups had no significant difference( P>0.05).Platelet count between the two groups before and after treatment had no obvious difference(P>0.05).2. Platelet aggregation rate(PAG):two groups of patients after treatment the PAG induced by arachidonic acid(AA) were significantly lower than before treatment(P<0.05).Comparison between the two groups, the treatment group A was lower than those of group B, PAG before was statistically significant(P<0.05);In the two groups after treatment the difference of PAG had no statistical significance( P>0.05).3. The blood coagulation function: two groups after treatment in patients with D-dimer, FIB and APTT compared with that before treatment were significantly improved( P<0.05);TT and PT before and after treatment were obviously improved in the two groups( P>0.05). Comparison between the two groups, the treatment in the first group D-dimer and blood coagulation had no significant difference( P>0.05); Group B after treatment FIB values compared with group A decreased significantly(P<0.05), APTT and D-dimer decreased without difference between the two groups( P>0.05).[Conclusion] As aspirin treatment alone, with Dan vermiculite hypoglycemic capsule can further reduce the level of PAG, two groups of patients improve the function of blood coagulation, for patients with diabetes mellitus in the lower plasma D-dimer, FIB and APTT level is more obvious.