CAJ | 학술논문

目的：探讨非小细胞肺癌（non －small cell lung cancer，NSCLC ）患者肺癌组织标本中 ERCC1和Pim －1的表达与临床特征及化疗疗效的相关性。方法：对我院病理确诊的70例 NSCLC 患者肿瘤组织，通过实时定量荧光 PCR 法检测 ERCC1和 Pim －1基因 mRNA 表达水平，回顾性分析 ERCC1和Pim －1基因表达与临床病理关系、铂类化疗疗效和总生存情况。结果：70例 NSCLC 患者肿瘤组织中 ERCC1和 Pim －1高表达患者比率分别为37．14％（26／70）和61．43％（43／70），ERCC1高表达与性别、吸烟史、组织类型、TNM 分期均无关（P ＞0．05），Pim －1高表达与性别、吸烟史相关（P ＜0．05），而与组织类型、TNM分期无关（P ＞0．05）。ERCC1和 Pim －1共同高表达率为20．00％（14／70）。ERCC1高表达组患者化疗有效率（19．23％，5／26）显著低于低表达组患者（47．73％，21／44）（P ＜0．05）。Pim －1高表达组患者化疗有效率（34．88％，15／43）和低表达组患者（40．74％，11／27）无统计学差异（P ＞0．05）。ERCC1和 Pim －1高表达组的中位生存期（median survival time，MST）为27个月和24个月低于低表达组的33个月和27个月，但无统计学差异（P ＞0．05）。结论：NSCLC 患者中 ERCC1低表达组患者化疗有效率和存活率高，是化疗受益的指标。
목적：탐토비소세포폐암（non －small cell lung cancer，NSCLC ）환자폐암조직표본중 ERCC1화Pim －1적표체여림상특정급화료료효적상관성。방법：대아원병리학진적70례 NSCLC 환자종류조직，통과실시정량형광 PCR 법검측 ERCC1화 Pim －1기인 mRNA 표체수평，회고성분석 ERCC1화Pim －1기인표체여림상병리관계、박류화료료효화총생존정황。결과：70례 NSCLC 환자종류조직중 ERCC1화 Pim －1고표체환자비솔분별위37．14％（26／70）화61．43％（43／70），ERCC1고표체여성별、흡연사、조직류형、TNM 분기균무관（P ＞0．05），Pim －1고표체여성별、흡연사상관（P ＜0．05），이여조직류형、TNM분기무관（P ＞0．05）。ERCC1화 Pim －1공동고표체솔위20．00％（14／70）。ERCC1고표체조환자화료유효솔（19．23％，5／26）현저저우저표체조환자（47．73％，21／44）（P ＜0．05）。Pim －1고표체조환자화료유효솔（34．88％，15／43）화저표체조환자（40．74％，11／27）무통계학차이（P ＞0．05）。ERCC1화 Pim －1고표체조적중위생존기（median survival time，MST）위27개월화24개월저우저표체조적33개월화27개월，단무통계학차이（P ＞0．05）。결론：NSCLC 환자중 ERCC1저표체조환자화료유효솔화존활솔고，시화료수익적지표。
Objective:To investigate the relationship of the expression of ERCC1 and Pim -1 with the clinical fac-tors and chemotherapeutic efficacy in patients with NSCLC.Methods:Seventy cases with NSCLC pathologically proven were analyzed retrospectively.The mRNA expressions of ERCC1 and Pim -1 were detected by Real -time quantita-tive PCR(RT -QPCR).The clinical factors and platinum -based chemotherapeutic efficacy in lung canser patients were observed.Results:The expression rates of ERCC1 and Pim -1 in patients with NSCLC were 37.14%(26 /70) and 61.43%(43 /70).The expression of ERCC1 was not related to gender,smoking,histological type,TNM stage(P>0.05).The expression of Pim -1 was not related to histological type,TNMstage(P >0.05),but it was related to gender,smoking.The co -overexpression of ERCC1 and Pim -1 in ESCLC patients was 20.00%(14 /70).The pa-tients with low expression of ERCC1 showed increased effective rate of chemotherapy compared to ERCC1 overexpres-sion group.No significant difference of chemotherapeutic effectiveness was found between the patients with low (34.88%,15 /43)and high(40.74%,11 /27)expression of Pim -1.The median survival times of the patients with high expression of ERCC1 or Pim -1 were lower than the patients with low expression of ERCC1 and Pim -1,but the difference was not statistically significant(P >0.05).Conclusion:The patients with low expression of ERCC1 showed higher effectiveness of chemotherapy and survival rate,which indicates that the expression of ERCC1 is related to tumor biological behivor.