CAJ | 학술논문

目的：评价肾癌患者术后应用干扰素免疫治疗对机体免疫水平的影响。方法：选取肾癌患者50例，术后应用干扰素（IFN）行免疫治疗，同时选取术后未行免疫治疗的肾癌患者45例作为对照组。于术前及术后1、2、3个月检测患者免疫指标（CD3＋、CD4＋、CD8＋、CD4＋／CD8＋、CD19＋、CD16＋56＋），比较两组间指标差异及手术前后免疫指标变化情况。结果：术前免疫治疗组与对照组间各项免疫指标差异无统计学意义（P ＞0．05）。术后1、2、3个月对照组各免疫指标与术前相比差异无统计学意义（P 均＞0．05），治疗组术后第2、3个月较术前均有显著差异（P ＜0．05、P ＜0．01）。结论：肾癌术后应用干扰素免疫治疗能有效提高机体免疫水平，对患者远期预后需进一步随访。
목적：평개신암환자술후응용간우소면역치료대궤체면역수평적영향。방법：선취신암환자50례，술후응용간우소（IFN）행면역치료，동시선취술후미행면역치료적신암환자45례작위대조조。우술전급술후1、2、3개월검측환자면역지표（CD3＋、CD4＋、CD8＋、CD4＋／CD8＋、CD19＋、CD16＋56＋），비교량조간지표차이급수술전후면역지표변화정황。결과：술전면역치료조여대조조간각항면역지표차이무통계학의의（P ＞0．05）。술후1、2、3개월대조조각면역지표여술전상비차이무통계학의의（P 균＞0．05），치료조술후제2、3개월교술전균유현저차이（P ＜0．05、P ＜0．01）。결론：신암술후응용간우소면역치료능유효제고궤체면역수평，대환자원기예후수진일보수방。
Objective:To evaluate the change of immune function in postoperative patients with renal cell carcino-ma treated with interferon.Methods:Fifty patients with renal cell carcinoma treated with interferon after operation consisted of the treatment group.The control group included 45 patients without any treatment after operation.Immune parameters,including CD3 +,CD4 +,CD8 +,CD4 +/CD8 +,CD19 + and CD16 +56 + were determined before and at the 1th,2nd,3th month after therapy.Results:The levels of detected immune parameters had no statistic difference before operation(P >0.05)between the two groups.In control group,the levels of immune parameters had no statistic differ-ence at the 1th,2nd,3th month after operation(P >0.05).However,statistic difference was found in treatment group at the 2nd and 3th month after operation(P <0.05,P <0.01).Conclusion:Interferon can increase the immune level of patients with renal cell carcinoma after operation,and its influence on the long -term survival needs further study.