CAJ | 학술논문

[目的]认识和探讨电针在脊髓神经干细胞损伤治疗领域的相关研究。[方法]应用计算机检索PubMed数据库2000年1月至2015年4月期间的有关神经干细胞和增殖、分化关系的文献,检索词为“EA,neural stem cell”，限定文章语种为“English”；同时应用计算机检索中国知网数据库2000年1月至2015年4月期间相关文献，检索词为“电针“”神经干细胞”，限定语种为中文。手工检索：《Nature》《针刺研究》。对检索到的电针对神经干细胞修复脊髓损伤的相关信息进行整理，从神经干细胞的特性、脊髓损伤后神经干细胞的自我修复以及电针对神经干细胞的影响这几个方面选取针对性较强的文献，排除重复性研究、meta分析。[结果]共检索47篇，符合纳入标准23篇。脊髓损伤后的修复是个复杂的机制，神经干细胞的提出改变了人们对中枢神经再生的认识，其具有多向分化潜能和迁移能力。神经干细胞能够分化为神经元、少突胶质细胞、星形胶质细胞，其增殖分化的方向受到多种因素的调节，而电针可以诱导其分化进而修复脊髓损伤。[结论]电针在诱导内源性神经干细胞增殖和分化方面具有其独特优势，有广阔的临床前景。但其具体诱导、分化机制尚未阐明，仍需大量研究。
[목적]인식화탐토전침재척수신경간세포손상치료영역적상관연구。[방법]응용계산궤검색PubMed수거고2000년1월지2015년4월기간적유관신경간세포화증식、분화관계적문헌,검색사위“EA,neural stem cell”，한정문장어충위“English”；동시응용계산궤검색중국지망수거고2000년1월지2015년4월기간상관문헌，검색사위“전침“”신경간세포”，한정어충위중문。수공검색：《Nature》《침자연구》。대검색도적전침대신경간세포수복척수손상적상관신식진행정리，종신경간세포적특성、척수손상후신경간세포적자아수복이급전침대신경간세포적영향저궤개방면선취침대성교강적문헌，배제중복성연구、meta분석。[결과]공검색47편，부합납입표준23편。척수손상후적수복시개복잡적궤제，신경간세포적제출개변료인문대중추신경재생적인식，기구유다향분화잠능화천이능력。신경간세포능구분화위신경원、소돌효질세포、성형효질세포，기증식분화적방향수도다충인소적조절，이전침가이유도기분화진이수복척수손상。[결론]전침재유도내원성신경간세포증식화분화방면구유기독특우세，유엄활적림상전경。단기구체유도、분화궤제상미천명，잉수대량연구。
Objective]To understand and explore the related research of electro-acupuncture in the field of injury spinal cord neural stem cell therapy. [Method]The computer-based online search of Pubmeddirect databases between January 2000 and April 2015 were undertaken to identify English literatures by using the key words of“EA,neural stem cells”. Meanwhile, relevant Chinese articles between January 2000 and April 2015 were searched in CNKI database with the key words of"EA,neural stem cell".Manual search:“Nature”,“Acupuncture research”. The retrieved articles from these aspects of the character of neural stem cell,neural stem cell repairing itself after spinal cord injury, EA promoting neural stem cell proliferation to repair was sorted out and the focused literatures were selected, repetitive researches and Meta analysis were depleted.[Result]Totally 47 articles were collected, and 23 met the inclusivecriteria. Repair of the after-loss spinal cord was a complex mechanism, and the proposition of the neural stem cells changed our understanding of the central nervous system regeneration, which had multi-directional differentiation potential and the migration ability. Neural stem cells can differentiate neurons, oligodendrocytes, astrocytes, the direction of its proliferation and differentiation regulated by a variety of factors, and EA can induce differentiation and then repair the spinal cord injury. [Conclusion]EA has its unique advantages in the induction of proliferation and differentiation of endogenous neural stem cells, and it can be effective for clinical application. But the specific mechanism about its induced differentiation has not been clarified, still needing a large number of researches.