现代肿瘤医学
現代腫瘤醫學
현대종류의학
Journal of Modern Oncology
2015年
22期
3273-3275
,共3页
胃癌%恶性肿瘤家族史%临床病理特征
胃癌%噁性腫瘤傢族史%臨床病理特徵
위암%악성종류가족사%림상병리특정
gastric cancer%familial history of malignant neoplasm(MN -FH)%clinicopathological characteristics
目的:探讨恶性肿瘤家族史(familial history of malignant neoplasm,MN -FH)对胃癌贡献比例及与临床病理特征之间的关系。方法:回顾我院2010年1月-2014年12月间收治的资料齐全的310例胃癌患者的临床病理资料,以有无肿瘤家族史分组,利用 SPSS 软件统计分析组间临床病理特征关系。结果:96例(31.0%)胃癌患者具有肿瘤家族史,其一级和二级亲属中共有64例(66.7%)具有消化道相关肿瘤,包括食管癌(19.8%)、胃癌(24.0%)、肝癌(6.3%)和结直肠癌(16.7%)。泌尿系肿瘤占12.5%,其他(包括甲状腺癌、乳腺癌、喉癌等)占20.8%。相关性分析显示有无肿瘤家族史在性别及肿瘤发生部位均没有差异(P >0.05)。病理分型显示有 MN -FH 的胃癌患者以低分化、未分化多见,占60.4%(58/96),无 MN -FH 占12.6%(27/214),两组相比,P <0.05。而在高、中分化腺癌类型上则相反,有 MN -FH 胃癌组占39.6%,无MN -FH 胃癌组占87.3%,P <0.05。胃癌临床分期显示有 MN -FH 多以Ⅲ、Ⅳ期为主(73.0%),无 MN -FH组以Ⅱ期为主(57.9%),两组相比,P <0.05,具有显著性差异。结论:我院超过1/3的胃癌患者具有阳性 MN-FH。其中最常见的 MN -FH 是消化道肿瘤。MN -FH 胃癌具有分化程度低,病理特征恶性程度高特点。对于有家族史人群定期体检非常重要,早诊和早治是提高生存率的关键。
目的:探討噁性腫瘤傢族史(familial history of malignant neoplasm,MN -FH)對胃癌貢獻比例及與臨床病理特徵之間的關繫。方法:迴顧我院2010年1月-2014年12月間收治的資料齊全的310例胃癌患者的臨床病理資料,以有無腫瘤傢族史分組,利用 SPSS 軟件統計分析組間臨床病理特徵關繫。結果:96例(31.0%)胃癌患者具有腫瘤傢族史,其一級和二級親屬中共有64例(66.7%)具有消化道相關腫瘤,包括食管癌(19.8%)、胃癌(24.0%)、肝癌(6.3%)和結直腸癌(16.7%)。泌尿繫腫瘤佔12.5%,其他(包括甲狀腺癌、乳腺癌、喉癌等)佔20.8%。相關性分析顯示有無腫瘤傢族史在性彆及腫瘤髮生部位均沒有差異(P >0.05)。病理分型顯示有 MN -FH 的胃癌患者以低分化、未分化多見,佔60.4%(58/96),無 MN -FH 佔12.6%(27/214),兩組相比,P <0.05。而在高、中分化腺癌類型上則相反,有 MN -FH 胃癌組佔39.6%,無MN -FH 胃癌組佔87.3%,P <0.05。胃癌臨床分期顯示有 MN -FH 多以Ⅲ、Ⅳ期為主(73.0%),無 MN -FH組以Ⅱ期為主(57.9%),兩組相比,P <0.05,具有顯著性差異。結論:我院超過1/3的胃癌患者具有暘性 MN-FH。其中最常見的 MN -FH 是消化道腫瘤。MN -FH 胃癌具有分化程度低,病理特徵噁性程度高特點。對于有傢族史人群定期體檢非常重要,早診和早治是提高生存率的關鍵。
목적:탐토악성종류가족사(familial history of malignant neoplasm,MN -FH)대위암공헌비례급여림상병리특정지간적관계。방법:회고아원2010년1월-2014년12월간수치적자료제전적310례위암환자적림상병리자료,이유무종류가족사분조,이용 SPSS 연건통계분석조간림상병리특정관계。결과:96례(31.0%)위암환자구유종류가족사,기일급화이급친속중공유64례(66.7%)구유소화도상관종류,포괄식관암(19.8%)、위암(24.0%)、간암(6.3%)화결직장암(16.7%)。비뇨계종류점12.5%,기타(포괄갑상선암、유선암、후암등)점20.8%。상관성분석현시유무종류가족사재성별급종류발생부위균몰유차이(P >0.05)。병리분형현시유 MN -FH 적위암환자이저분화、미분화다견,점60.4%(58/96),무 MN -FH 점12.6%(27/214),량조상비,P <0.05。이재고、중분화선암류형상칙상반,유 MN -FH 위암조점39.6%,무MN -FH 위암조점87.3%,P <0.05。위암림상분기현시유 MN -FH 다이Ⅲ、Ⅳ기위주(73.0%),무 MN -FH조이Ⅱ기위주(57.9%),량조상비,P <0.05,구유현저성차이。결론:아원초과1/3적위암환자구유양성 MN-FH。기중최상견적 MN -FH 시소화도종류。MN -FH 위암구유분화정도저,병리특정악성정도고특점。대우유가족사인군정기체검비상중요,조진화조치시제고생존솔적관건。
Objective:To investigate the clinicopathological characteristics and familial history of malignant neo-plasm (MN -FH)of gastric cancer patients.Methods:The clinical data of 310 cancer cases in our hospital during January 2010 to December 2014 were analyzed retrospectively.Results:96 cases (31.0%)patients of gastric cancer had family history of cancer.Of the primary and secondary relatives,64 cases (66.7%)had digestive tract tumors, including esophageal cancer (19.8%),gastric cancer (24.0%),liver (6.3%)and colorectal cancer (16.7%).U-rinary system tumor accounted for 12.5%,other (including thyroid cancer,breast cancer,laryngeal cancer,etc.)ac-counted for 20.8%.The correlation analysis showed that there was no difference between MN -FH and sex,the loca-tion of tumor (P >0.05).The pathological typing showed that gastric cancer patients with MN -FH were mainly low differentiation and not differentiation,accounting for 60.4%(58 /96),no MN -FH accounted for 12.6%(27 /214), compared with the two group,P <0.05.While in the high and medium differentiated adenocarcinoma types,there was 39.6% in MN -FH gastric cancer patients,was 7.3% in no MN -FH gastric cancer group,P <0.05.The clinical staging of gastric cancer showed that gastric cancer patients with MN -FH were mainly IV stage (73.0%),and no MN -FH group (57.9%),P <0.05.Conclusion:Over 1 /3 in our hospital patients of gastric cancer had a positive MN -FH.The most common forms is gastrointestinal cancer.MN -FH gastric cancer has the features of low differen-tiation degree and high pathological features of malignant degree.It is important to early diagnoze and treat patients of gastric cancer with positive MN -FH.