CAJ | 학술논문

目的：研究接头蛋白 DOK2在结直肠癌中的表达及其临床病理学意义。方法：免疫组化检测87例结直肠癌组织中 DOK2的表达，并对结直肠癌患者进行生存分析。结果：DOK2在63例（72％）结直肠癌组织中表达阴性，在正常组织中表达阳性。DOK2表达丢失与肿瘤分化程度（P ＝0．001）和复发（P ＝0．048）之间有显著相关性。COX 回归分析显示，DOK2表达丢失是结直肠癌患者总体生存率（overall survival，OS）（P ＝0．001）和无复发生存率（recurrence －free survival，RFS）（P ＝0．006）的独立影响因素。Kaplan －Meier 法生存分析表明，与 DOK2表达阳性的患者相比，DOK2表达阴性的患者中位生存时间显著缩短（46个月 vs 53个月，P ＜0．001），无复发中位生存时间也显著缩短（36个月 vs 49个月，P ＜0．001）。结论：接头蛋白 DOK2是结直肠癌患者预后的独立影响因素。
목적：연구접두단백 DOK2재결직장암중적표체급기림상병이학의의。방법：면역조화검측87례결직장암조직중 DOK2적표체，병대결직장암환자진행생존분석。결과：DOK2재63례（72％）결직장암조직중표체음성，재정상조직중표체양성。DOK2표체주실여종류분화정도（P ＝0．001）화복발（P ＝0．048）지간유현저상관성。COX 회귀분석현시，DOK2표체주실시결직장암환자총체생존솔（overall survival，OS）（P ＝0．001）화무복발생존솔（recurrence －free survival，RFS）（P ＝0．006）적독립영향인소。Kaplan －Meier 법생존분석표명，여 DOK2표체양성적환자상비，DOK2표체음성적환자중위생존시간현저축단（46개월 vs 53개월，P ＜0．001），무복발중위생존시간야현저축단（36개월 vs 49개월，P ＜0．001）。결론：접두단백 DOK2시결직장암환자예후적독립영향인소。
Objective:To investigate the clinicopathological significance of DOK2 expression in colorectal cancer. Methods:Expression of adaptor protein DOK2 was detected immuno -histochemically.And the survival of the color-ectal cancer patients was analysed.Results:Loss of DOK2 expression was detected in 67 tissue samples (72%)of colorectal cancer.Meanwhile DOK2 was positively detected in normal tissue.Loss of DOK2 expression was significant-ly related with tumor differentiation (P =0.001)and tumor recurrence (P =0.048).COX regression analysis indica-ted that loss of DOK2 expression was independent predictor of overall survival (OS)(P =0.001)and recurrence -free survival (RFS)(P =0.006).Kaplan -Meier survival analysis showed that,compared with patients with positive expression of DOK2,patients with loss of DOK2 expression had a shortened median survival time (46 months vs 53 months,P <0.001)and shortened recurrence -free survival time (36 months vs 49 months,P <0.001).Conclu-sion:Loss of DOK2 expression is an independent prognostic factor in patients with colorectal cancer.