现代肿瘤医学
現代腫瘤醫學
현대종류의학
Journal of Modern Oncology
2015年
22期
3333-3335
,共3页
谢楚海%吴波以%史群伟%陈斌伟%郭剑鸿
謝楚海%吳波以%史群偉%陳斌偉%郭劍鴻
사초해%오파이%사군위%진빈위%곽검홍
转移性骨肿瘤%89 SrCl2%99 Tc -MDP%核素治疗
轉移性骨腫瘤%89 SrCl2%99 Tc -MDP%覈素治療
전이성골종류%89 SrCl2%99 Tc -MDP%핵소치료
metastatic bone tumor%89 SrCl2%99 Tc -MDP%nuclide therapy
目的：评价氯化锶（89 SrCl2）与99锝－二甲基二磷酸盐（99 Tc －MDP）联合治疗转移性骨肿瘤的临床疗效及不良反应发生情况。方法：将转移性骨肿瘤患者126名随机分为89 SrCl2联合99 Tc －MDP 治疗组及89 SrCl2单项治疗组进行治疗，比较两组疼痛反应情况、骨转移灶的治疗情况以及不良反应的发生率。结果：对于转移性骨肿瘤的镇痛效果，联合治疗组患者中，有效率为23．81％，显效率61．90％，无效率14．29％；单项治疗组患者有效率为12．70％，显效率58．73％，无效率28．57％，两组患者镇痛疗效的差异具有统计学意义（P ＜0．01）。对于转移性骨肿瘤骨转移灶的治疗效果和不良反应发生率，联合治疗组患者中和单项治疗组患者的差异无统计学意义（P ＞0．05）。结论：氯化锶（89 SrCl2）与99锝－二甲基二磷酸盐（99 Tc －MDP）联合治疗转移性骨肿瘤疼痛具有明显的效果，也可消退部分转移病灶，不良反应发生率较低，临床效果优于89 SrCl2单项治疗效果。
目的：評價氯化鍶（89 SrCl2）與99锝－二甲基二燐痠鹽（99 Tc －MDP）聯閤治療轉移性骨腫瘤的臨床療效及不良反應髮生情況。方法：將轉移性骨腫瘤患者126名隨機分為89 SrCl2聯閤99 Tc －MDP 治療組及89 SrCl2單項治療組進行治療，比較兩組疼痛反應情況、骨轉移竈的治療情況以及不良反應的髮生率。結果：對于轉移性骨腫瘤的鎮痛效果，聯閤治療組患者中，有效率為23．81％，顯效率61．90％，無效率14．29％；單項治療組患者有效率為12．70％，顯效率58．73％，無效率28．57％，兩組患者鎮痛療效的差異具有統計學意義（P ＜0．01）。對于轉移性骨腫瘤骨轉移竈的治療效果和不良反應髮生率，聯閤治療組患者中和單項治療組患者的差異無統計學意義（P ＞0．05）。結論：氯化鍶（89 SrCl2）與99锝－二甲基二燐痠鹽（99 Tc －MDP）聯閤治療轉移性骨腫瘤疼痛具有明顯的效果，也可消退部分轉移病竈，不良反應髮生率較低，臨床效果優于89 SrCl2單項治療效果。
목적：평개록화송（89 SrCl2）여99득－이갑기이린산염（99 Tc －MDP）연합치료전이성골종류적림상료효급불량반응발생정황。방법：장전이성골종류환자126명수궤분위89 SrCl2연합99 Tc －MDP 치료조급89 SrCl2단항치료조진행치료，비교량조동통반응정황、골전이조적치료정황이급불량반응적발생솔。결과：대우전이성골종류적진통효과，연합치료조환자중，유효솔위23．81％，현효솔61．90％，무효솔14．29％；단항치료조환자유효솔위12．70％，현효솔58．73％，무효솔28．57％，량조환자진통료효적차이구유통계학의의（P ＜0．01）。대우전이성골종류골전이조적치료효과화불량반응발생솔，연합치료조환자중화단항치료조환자적차이무통계학의의（P ＞0．05）。결론：록화송（89 SrCl2）여99득－이갑기이린산염（99 Tc －MDP）연합치료전이성골종류동통구유명현적효과，야가소퇴부분전이병조，불량반응발생솔교저，림상효과우우89 SrCl2단항치료효과。
Objective:To assess the clinical effect and adverse effect of combination of 89 SrCl2 and 99 Tc -MDP in treatment of metastatic bone tumor.Methods:A total of 126 patients were randomly divided into combination treat-ment group treated with 89 SrCl2 and 99 Tc -MDP and single treatment group treated with 89 SrCl2 .The pain,treatment efficacy and adverse effect of metastatic bone tumor were compared between the two groups.Results:The effective rate of combination treatment group was 23.81%.The recovery rate was 61.90% and ineffective rate was 14.29%.The effective rate,recovery rate and ineffective rate of single treatment group were 12.70%,58.73% and 28.57% respec-tively.Significant difference was found between the two groups (P <0.01).For treatment efficacy and adverse effect, there was no significant difference between the combination treatment group and single treatment group (P >0.05). Conclusion:89 SrCl2 and 99 Tc -MDP had significant effect on controlling pain,eliminating metastatic lesion and de-creasing the adverse effect,which was better than the efficacy of 89 SrCl2 treatment.
