CAJ | 학술논문

目的：探究 YAP 和 TAZ 在人骨肉瘤组织中的表达及其与临床病理之间的相关性。方法：使用免疫组织化学方法对47例骨肉瘤组织及20例骨软骨瘤组织中的 YAP 和 TAZ 进行检测。结果：YAP 在骨肉瘤和骨软骨瘤中的阳性表达率分别为74．5％和30％。TAZ 在骨肉瘤和骨软骨瘤中的阳性表达率分别为59．6％和15％。YAP 与骨肉瘤的大小（P ＜0．05）有关；而 TAZ 则与骨肉瘤的远处转移及 Ennecking 分期有关（P＜0．05）。结论：YAP 和 TAZ 在恶性骨肉瘤中的高表达，预示着 YAP 和 TAZ 参与了肿瘤的发生发展及骨肉瘤的远处转移，为治疗骨肉瘤及骨肉瘤肺部转移提供了新的思路，为研制治疗骨肉瘤药物提供新靶点。
목적：탐구 YAP 화 TAZ 재인골육류조직중적표체급기여림상병리지간적상관성。방법：사용면역조직화학방법대47례골육류조직급20례골연골류조직중적 YAP 화 TAZ 진행검측。결과：YAP 재골육류화골연골류중적양성표체솔분별위74．5％화30％。TAZ 재골육류화골연골류중적양성표체솔분별위59．6％화15％。YAP 여골육류적대소（P ＜0．05）유관；이 TAZ 칙여골육류적원처전이급 Ennecking 분기유관（P＜0．05）。결론：YAP 화 TAZ 재악성골육류중적고표체，예시착 YAP 화 TAZ 삼여료종류적발생발전급골육류적원처전이，위치료골육류급골육류폐부전이제공료신적사로，위연제치료골육류약물제공신파점。
Objective:To explore the expression of YAP and TAZ in osteosarcoma and analyze the relationship be-tween the expression and clinical pathology.Methods:Using immunohistochemical staining to detect the expression of YAP and TAZ in 47 cases of osteosarcoma tissues and 20 cases of osteochondroma tissues.Results:The positive ex-pression rate of YAP was 74.5% in osteosarcoma and 30% in osteochondroma,while TAZ was 59.6% in osteosarco-ma and 15% in osteochondroma.There was a link between YAP expression and diameter of osteosarcoma(P <0.05). Meanwhile,TAZ was associated with distant metastasis and Ennecking stages of osteosarcoma(P <0.05).Conclu-sion:The high expression of YAP and TAZ in malignant tumors suggests that YAP and TAZ involve in the osteosarco-ma progression and distant metastasis.This can provide a new idea to cure the osteosarcoma and distant metastasis and offer a new target for the drug.