大家健康（下旬版）
大傢健康（下旬版）
대가건강（하순판）
For All Health
2015年
9期
16-17
,共2页
单唾液酸四已糖神经节苷脂%鼠神经生长因子%新生儿缺氧缺血性脑病
單唾液痠四已糖神經節苷脂%鼠神經生長因子%新生兒缺氧缺血性腦病
단타액산사이당신경절감지%서신경생장인자%신생인결양결혈성뇌병
Monosialotetrahexosylganglioside%mouse Nerve Growth Factor%Neonatal Hypoxic-Ischemic Emcephalopathy
目的:观察单唾液酸四已糖神经节苷脂(GM -1)联合鼠神经生长因子(mNGF)治疗新生儿缺氧缺血性脑病(HIE)的临床疗效.方法 :选择我院儿科住院 HIE患儿51例 ,均采用三维持、三对症综合治疗方案 ,对照组25例加用单唾液酸四已糖神经节苷脂治疗 ,治疗组 26例在对照组的基础上加用鼠神经生长因子治疗 ,观察两组患儿的症状体征 ,新生儿神经行为评分(NBNA)评估疗效.结果 :治疗组临床疗效总有效率96 .1% ,显著高于对照组 ;NABA评分 ,治疗组与对照组在生后2d内评分无明显差异 ,生后10 天评分治疗组明显高于对照组.差异均具有统计学意义(P< 0 .05).结论 :GM -1联合 mNGF治疗新生儿缺氧缺血性脑病 ,能有效改善患儿的临床症状 ,可促进受损神经细胞功能修复 ,值得临床推广.
目的:觀察單唾液痠四已糖神經節苷脂(GM -1)聯閤鼠神經生長因子(mNGF)治療新生兒缺氧缺血性腦病(HIE)的臨床療效.方法 :選擇我院兒科住院 HIE患兒51例 ,均採用三維持、三對癥綜閤治療方案 ,對照組25例加用單唾液痠四已糖神經節苷脂治療 ,治療組 26例在對照組的基礎上加用鼠神經生長因子治療 ,觀察兩組患兒的癥狀體徵 ,新生兒神經行為評分(NBNA)評估療效.結果 :治療組臨床療效總有效率96 .1% ,顯著高于對照組 ;NABA評分 ,治療組與對照組在生後2d內評分無明顯差異 ,生後10 天評分治療組明顯高于對照組.差異均具有統計學意義(P< 0 .05).結論 :GM -1聯閤 mNGF治療新生兒缺氧缺血性腦病 ,能有效改善患兒的臨床癥狀 ,可促進受損神經細胞功能脩複 ,值得臨床推廣.
목적:관찰단타액산사이당신경절감지(GM -1)연합서신경생장인자(mNGF)치료신생인결양결혈성뇌병(HIE)적림상료효.방법 :선택아원인과주원 HIE환인51례 ,균채용삼유지、삼대증종합치료방안 ,대조조25례가용단타액산사이당신경절감지치료 ,치료조 26례재대조조적기출상가용서신경생장인자치료 ,관찰량조환인적증상체정 ,신생인신경행위평분(NBNA)평고료효.결과 :치료조림상료효총유효솔96 .1% ,현저고우대조조 ;NABA평분 ,치료조여대조조재생후2d내평분무명현차이 ,생후10 천평분치료조명현고우대조조.차이균구유통계학의의(P< 0 .05).결론 :GM -1연합 mNGF치료신생인결양결혈성뇌병 ,능유효개선환인적림상증상 ,가촉진수손신경세포공능수복 ,치득림상추엄.
Objective:To observe the clinieal effieacy of the monosialotetrahexosylganglioside(GM1) combined with mouse nerve growth factor (mNGF) in the treatment of neonatal hypoxic-ischemic encephalopathy(HIE) .Methods:In our hospital department of pediatric 51 cases of with neo-natal HIE were retrospectively analyzed .All the cases were treated by three in the support and the basis of the three symptomatic .The control group (n=25) was treated with GM1 together with conventional treraply for HIE .The treatment group(n=26) was treated with mNGF on the basis of the control group .There were statistical significant differences of symptoms and signs difference between the two groups .The neonatal behavioral neuro-logical assessment(NBNA) scores were evaluated between the two groups .Results :The total effective rate in the observation group was 96 .1% ,signifi-cantly higher than the control group .In the treatment group the NBNA scores(2d) was no significant difference ,In the treatment group the NBNA scores(10d) was significantly higher than that in the control group(p<0 .05) .Conclusions:GM1 Combined With mNGF treated the Neonatal Hypoxic-Ischemic encephalopathy ,can effectively improve the patients clinical symptoms .It Could significantly promote the injury central nerous system func-tional recovery .Thus it's worthy of clinical application .
