CAJ | 학술논문

目的:研究12-脂氧合酶(12-lipoxygenase,12-LOX)在神经胶质瘤中的表达及其临床意义.方法:免疫组织化学法检测40例神经胶质瘤组织和10例正常脑组织中12-LOX表达,结合临床随访资料探讨其表达与预后的相关性.结果:正常脑组织中12-LOX呈弱阳性表达,神经胶质瘤组织中强阳性表达率为72.5%,差异有统计学意义(P<0.05).12-LOX强阳性表达与神经胶质瘤病理级别相关,差异有统计学意义(P=0.012),与患者性别、年龄、肿瘤大小、KPS评分无关.12-LOX强阳性表达患者中位无瘤生存期明显低于与弱阳性表达患者(P<0.05).结论:12-LOX在神经胶质瘤中异常表达,其表达差异与神经胶质瘤的病理级别相关,与预后密切相关.
목적:연구12-지양합매(12-lipoxygenase,12-LOX)재신경효질류중적표체급기림상의의.방법:면역조직화학법검측40례신경효질류조직화10례정상뇌조직중12-LOX표체,결합림상수방자료탐토기표체여예후적상관성.결과:정상뇌조직중12-LOX정약양성표체,신경효질류조직중강양성표체솔위72.5%,차이유통계학의의(P<0.05).12-LOX강양성표체여신경효질류병리급별상관,차이유통계학의의(P=0.012),여환자성별、년령、종류대소、KPS평분무관.12-LOX강양성표체환자중위무류생존기명현저우여약양성표체환자(P<0.05).결론:12-LOX재신경효질류중이상표체,기표체차이여신경효질류적병리급별상관,여예후밀절상관.
Objective:To investigate the expression and clinical significance of 12-lipoxygenase (12-LOX) in glioma. Methods:12-LOX expression in 40 glioma cases and 10 normal human-brain tissues was assayed by immunohistochemistry. Clinicopathological data were analyzed to reveal the association between 12-LOX expression and prognosis of glioma patients. Results:12-LOX was weak-ly expressed in the normal human brain tissues, whereas 12-LOX was strongly expressed (72.5%) in glioma tissues (P<0.05). The strong 12-LOX expression was correlated with the histopathological grading of glioma (P=0.012), whereas 12-LOX expression was not correlated with factors such as patient gender and age, tumor size, and Karnofsky Performance Score. Median survival time was longer in the group with low 12-LOX expression (25.6 months) than in the group with high 12-LOX expression (13.2 months) (P<0.05). Con-clusion:Abnormal 12-LOX expression is implicated in glioma. 12-LOX expression was correlated with the histopathological grading of glioma and was closely associated with patient prognosis.