中国中西医结合急救杂志
中國中西醫結閤急救雜誌
중국중서의결합급구잡지
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
2015年
5期
467-471
,共5页
肺炎,重症%痰热腑实证%白虎加人参汤%复方薤白胶囊
肺炎,重癥%痰熱腑實證%白虎加人參湯%複方薤白膠囊
폐염,중증%담열부실증%백호가인삼탕%복방해백효낭
Severe pneumonia%Heat-phlegm and sthenic-fu syndrome%Baihu Rensen decoction%Fufang Xiebai capsules
目的 探讨白虎加人参汤联合复方薤白胶囊对重症肺炎痰热腑实证患者的临床疗效.方法 采用前瞻性研究方法,选择2012年1月至2013年12月江苏大学附属昆山市第一人民医院呼吸科病房收治的266例痰热腑实型重症肺炎患者,按简单随机方法分为中西医结合治疗组136例和西医治疗对照组130例.两组均根据病情给予西医基础治疗;中西医结合组在西医治疗的基础上加用白虎加人参汤联合复方薤白胶囊350 mg,每日3次,每次4粒(每粒350 mg),7 d为1个疗程.比较两组患者体温下降速度、中医症状改善程度、外周血白细胞计数(WBC)、中性粒细胞比例及内源性致热原产生的情况.结果 两组治疗后体温、中医症状积分、WBC、中性粒细胞比例均较治疗前降低,均于治疗后3 d达谷值,且以中西医结合治疗组降低更显著〔体温(℃):36.5±0.0比37.0±0.0,中医症状积分(分):1.7±0.2比6.1±0.7,WBC(×109/L):7.1±0.3比8.3±0.5,中性粒细胞比例:0.64±0.02比0.76±0.23,均P<0.05〕.以西医治疗对照组治疗后白细胞介素-1β(IL-1β)、 肿瘤坏死因子-α(TNF-α)、干扰素(IFN-α、IFN-γ)、白细胞介素-6(IL-6)水平为1,中西医结合治疗组治疗后6 h IL-1β、TNF-α、IFN-α、IFN-γ、IL-6均较西医治疗对照组明显下降,12 h到达谷值〔IL-1β、TNF-α、IFN-α、IFN-γ、IL-6与西医治疗对照组的相对表达量分别为0.37、0.16、0.21、0.27、0.15〕,24 h又有轻度回升.结论 加用白虎加人参汤联合用复方薤白胶囊治疗痰热腑实型重症肺炎患者具有良好的疗效.
目的 探討白虎加人參湯聯閤複方薤白膠囊對重癥肺炎痰熱腑實證患者的臨床療效.方法 採用前瞻性研究方法,選擇2012年1月至2013年12月江囌大學附屬昆山市第一人民醫院呼吸科病房收治的266例痰熱腑實型重癥肺炎患者,按簡單隨機方法分為中西醫結閤治療組136例和西醫治療對照組130例.兩組均根據病情給予西醫基礎治療;中西醫結閤組在西醫治療的基礎上加用白虎加人參湯聯閤複方薤白膠囊350 mg,每日3次,每次4粒(每粒350 mg),7 d為1箇療程.比較兩組患者體溫下降速度、中醫癥狀改善程度、外週血白細胞計數(WBC)、中性粒細胞比例及內源性緻熱原產生的情況.結果 兩組治療後體溫、中醫癥狀積分、WBC、中性粒細胞比例均較治療前降低,均于治療後3 d達穀值,且以中西醫結閤治療組降低更顯著〔體溫(℃):36.5±0.0比37.0±0.0,中醫癥狀積分(分):1.7±0.2比6.1±0.7,WBC(×109/L):7.1±0.3比8.3±0.5,中性粒細胞比例:0.64±0.02比0.76±0.23,均P<0.05〕.以西醫治療對照組治療後白細胞介素-1β(IL-1β)、 腫瘤壞死因子-α(TNF-α)、榦擾素(IFN-α、IFN-γ)、白細胞介素-6(IL-6)水平為1,中西醫結閤治療組治療後6 h IL-1β、TNF-α、IFN-α、IFN-γ、IL-6均較西醫治療對照組明顯下降,12 h到達穀值〔IL-1β、TNF-α、IFN-α、IFN-γ、IL-6與西醫治療對照組的相對錶達量分彆為0.37、0.16、0.21、0.27、0.15〕,24 h又有輕度迴升.結論 加用白虎加人參湯聯閤用複方薤白膠囊治療痰熱腑實型重癥肺炎患者具有良好的療效.
목적 탐토백호가인삼탕연합복방해백효낭대중증폐염담열부실증환자적림상료효.방법 채용전첨성연구방법,선택2012년1월지2013년12월강소대학부속곤산시제일인민의원호흡과병방수치적266례담열부실형중증폐염환자,안간단수궤방법분위중서의결합치료조136례화서의치료대조조130례.량조균근거병정급여서의기출치료;중서의결합조재서의치료적기출상가용백호가인삼탕연합복방해백효낭350 mg,매일3차,매차4립(매립350 mg),7 d위1개료정.비교량조환자체온하강속도、중의증상개선정도、외주혈백세포계수(WBC)、중성립세포비례급내원성치열원산생적정황.결과 량조치료후체온、중의증상적분、WBC、중성립세포비례균교치료전강저,균우치료후3 d체곡치,차이중서의결합치료조강저경현저〔체온(℃):36.5±0.0비37.0±0.0,중의증상적분(분):1.7±0.2비6.1±0.7,WBC(×109/L):7.1±0.3비8.3±0.5,중성립세포비례:0.64±0.02비0.76±0.23,균P<0.05〕.이서의치료대조조치료후백세포개소-1β(IL-1β)、 종류배사인자-α(TNF-α)、간우소(IFN-α、IFN-γ)、백세포개소-6(IL-6)수평위1,중서의결합치료조치료후6 h IL-1β、TNF-α、IFN-α、IFN-γ、IL-6균교서의치료대조조명현하강,12 h도체곡치〔IL-1β、TNF-α、IFN-α、IFN-γ、IL-6여서의치료대조조적상대표체량분별위0.37、0.16、0.21、0.27、0.15〕,24 h우유경도회승.결론 가용백호가인삼탕연합용복방해백효낭치료담열부실형중증폐염환자구유량호적료효.
Objective To study the effects of Baihu Rensen decoction combined with Fufang Xiebai capsules for treatment of patients with severe pneumonia accompanied by heat-phlegm and sthenic-fu syndrome.Methods A prospective study was conducted; 266 severe pneumonia cases with heat-phlegm and sthenic-fu syndrome admitted into the Department of Respiratory Diseases in Kunshan Hospital Affiliated to Jiangsu University from January 2012 to December 2013 were selected. The patients were randomly divided into a integrated traditional Chinese and western medicine group (136 cases) and a western medicine treatment group (130 cases). Both groups were given basic conventional western medicine according to the disease situation. The integrated traditional Chinese medicine (TCM) was additionally given Baihu Rensen decoction combined with 350 mg of Fufang Xiebai capsules, 3 times a day, 4 grain each time, 7 days constituting a course of treatment. The rate of body temperature descent, the degree of improvement in clinical TCM symptoms, peripheral white blood cell (WBC) count, neutrophil percentage and the situation of endogenous pyrogen production in the two groups were compared.Results After treatment, the body temperature, TCM symptom scores, WBC count and neutrophil percentage were lower than those before treatment, 3 days after treatment these data reached their valley values, and the decrease in level was more significant in the combination group [body temperature (℃): 36.5±0.0 vs. 37.0±0.0, TCM symptom scores: 1.7±0.2 vs. 6.1±0.7, WBC (×109/L): 7.1±0.3 vs. 8.3±0.5, neutrophil percentage: 0.64±0.02 vs. 0.76±0.23, allP < 0.05]. Interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), interferon (IFN-α, IFN-γ), and interleukin-6 (IL-6) level in western medicine (WM) group was respectively marked 1, the levels of IL-1β, TNF-α, IFN-α, IFN-γ, and IL-6 in combination group after treatment for 6 hours were significantly lower than those of WM group, and reached the valley at 12 hours (the relative expression value of each of the above indexes in combination group to each of those in WM group was 0.37, 0.16, 0.21, 0.27 and 0.15 respectively), and had a mild rebound at 24 hours.Conclusion By the addition of Baihu Rensen decoction combined with Fufang Xiebai capsules on conventional basic medicine for treatment of severe pneumonia patients with heat-phlegm and sthenic-fu syndrome, the therapeutic effect is much better.
