CAJ | 학술논문

目的：探讨阿托伐他汀钙联合曲美他嗪对慢性心力衰竭（CHF）患者心功能的影响。方法将86例慢性心力衰竭患者随机分为对照组、曲美他嗪联合阿托伐他汀组治疗组，对照组行常规抗心衰治疗，治疗组在常规抗心衰治疗的基础上加用阿托伐他汀钙联合曲美他嗪，所有患者在治疗前及治疗24周后检测左室射血分数（LVEF）、每搏输出量（SV）和左室内径（LVEDD）、血清C反应蛋白（CRP）、血浆脑利钠肽（BNP）、6分钟步行试验行走距离。结果与治疗前相比。各组治疗后LVEF、LVEDD、SV明显改善（P<0.05），血清C反应蛋白（CRP）及BNP水平显著下降，6分钟步行试验行走距离延长，阿托伐他汀钙联合曲美他嗪治疗组BNP水平下降较对照组更为显著（均P<0.05），6分钟步行试验行走距离显著延长（P<0.05）。结论在常规治疗的基础上加用阿托伐他汀钙联合曲美他嗪可进一步降低心力衰竭患者血液中CRP、BNP水平，发挥抗炎作用，同时降低心衰患者心肌耗氧，可以明显改善患者心功能。6分钟步行试验行走距离显著延长，提高了患者的运动耐量。
목적：탐토아탁벌타정개연합곡미타진대만성심력쇠갈（CHF）환자심공능적영향。방법장86례만성심력쇠갈환자수궤분위대조조、곡미타진연합아탁벌타정조치료조，대조조행상규항심쇠치료，치료조재상규항심쇠치료적기출상가용아탁벌타정개연합곡미타진，소유환자재치료전급치료24주후검측좌실사혈분수（LVEF）、매박수출량（SV）화좌실내경（LVEDD）、혈청C반응단백（CRP）、혈장뇌리납태（BNP）、6분종보행시험행주거리。결과여치료전상비。각조치료후LVEF、LVEDD、SV명현개선（P<0.05），혈청C반응단백（CRP）급BNP수평현저하강，6분종보행시험행주거리연장，아탁벌타정개연합곡미타진치료조BNP수평하강교대조조경위현저（균P<0.05），6분종보행시험행주거리현저연장（P<0.05）。결론재상규치료적기출상가용아탁벌타정개연합곡미타진가진일보강저심력쇠갈환자혈액중CRP、BNP수평，발휘항염작용，동시강저심쇠환자심기모양，가이명현개선환자심공능。6분종보행시험행주거리현저연장，제고료환자적운동내량。
Objective This study is to discuss the effects on chronic heart failure (CHF) patients treated by atorvastatin calcium combined with trimetazidine.Methods 86 patients with CHF were randomly divided into two groups: control group (treated by conventional therapy) and treatment group (cured by atorvastatin calcium combined with trimetazidine, based on the conventional therapy). Then these indexes as follow were compared before therapies and after 24 weeks:left ventricular ejection fraction (LVEF), stroke volume (SV), left ventricular diameter (LVEDD), serum C-reactive protein (CRP), sodium plasma brain natriuretic peptide (BNP) and the distance of 6 minutes walking test.Results Compared with the previous treatment, after treatment each group improved significantly in LVEF, LVEDD and SV (P<0.05), and the leves of CRP and BNP were significantly decreased after treatment, and the distances of 6 minutes walking were extended. Furthermore, the BNP levels of treatment group cured by atorvastatin calcium combined with trimetazidine decreased significantly more than the control group (all P<0.05), and the distance of 6 minutes walking test were significantly longer (P<0.05).Conclusion On the basis of conventional, therapy plus atorvastatin calcium combined with trimetazidine may further reduce the CRP and BNP levels of patients with heart failure in blood. In addition, anti-inflammatory effects, myocardial oxygen consumption reducing and significantly improvement of patients' heart function were all act in therapy group. Significantly extend distance of the 6 minutes walking test were improved the exercise tolerance in patients.