CAJ | 학술논문

目的：：明确儿童急性泛发型脓疱性银屑病(AGPP)血小板参数、C反应蛋白(CRP)及嗜酸粒细胞水平变化。方法：检测41例儿童AGPP患者、37例健康儿童对照及31例儿童寻常型银屑病患者( PV)血小板参数、CRP及嗜酸粒细胞水平。结果： AGPP进展期PLT计数、血小板压积( PCT)， CRP均显著高于儿童PV患者及儿童正常对照组( P<0.05)。进展期AGPP患者嗜酸粒细胞百分比和平均血小板体积(MPV)显著低于其他两组(P<0.05)。嗜酸粒细胞计数与对照组无明显差异(P>0.05)。消退期AGPP患者PLT计数、PCT及CRP显著低于进展期AGPP患者( P<0.05)。结论：血小板参数及CRP水平可作为AGPP病程进展及治疗评价的参考指标。
목적：：명학인동급성범발형농포성은설병(AGPP)혈소판삼수、C반응단백(CRP)급기산립세포수평변화。방법：검측41례인동AGPP환자、37례건강인동대조급31례인동심상형은설병환자( PV)혈소판삼수、CRP급기산립세포수평。결과： AGPP진전기PLT계수、혈소판압적( PCT)， CRP균현저고우인동PV환자급인동정상대조조( P<0.05)。진전기AGPP환자기산립세포백분비화평균혈소판체적(MPV)현저저우기타량조(P<0.05)。기산립세포계수여대조조무명현차이(P>0.05)。소퇴기AGPP환자PLT계수、PCT급CRP현저저우진전기AGPP환자( P<0.05)。결론：혈소판삼수급CRP수평가작위AGPP병정진전급치료평개적삼고지표。
Objective:To determine the changes of the levels of peripheral blood platelet parameters, Cre-active protein (CRP) and eosnophils (EOS) in children with acute generalized pustular psoriasis (AGPP). Methods:The levels of peripheral blood platelet parameters, CRP and EOS in 41 children with AGPP, 37 healthy children and 31 children with psoriasis vulgaris were detected. Results: The levels of PLT count, platelet hematocrit ( PCT) and CRP in the active stage of AGPP group were higher than those in the other two groups ( P<0.05) . The mean platelet volume ( MPV) and EOS percentage were lower than those in the other two groups (P<0.05). There was no significant difference of EOS count among the three groups (P>0.05). The levels of PLT count, PCT and CRP in the recovery stage of AGPP were lower than those in active stage. Conclusion:Platelet parameters and CRP level could be as assistant indicators in monitoring the progression of children with AGPP.