医药与保健
醫藥與保健
의약여보건
Medicine and Health Care
2015年
9期
36-37
,共2页
肺炎支原体感染%锌缺乏%免疫功能%儿童
肺炎支原體感染%鋅缺乏%免疫功能%兒童
폐염지원체감염%자결핍%면역공능%인동
Mycoplasma pneumoniae infection%Zinc deficiency%immune function%Children
目的：探讨支原体感染儿童血清锌水平与免疫功能变化。方法检测38例支原体感染患儿和20例健康儿童血清锌水平及免疫功能。结果①支原体感染组儿童血清锌水平低于健康对照组水平，差异有统计学意义（P<0.01）。锌缺乏在支原体感染组和对照组的阳性率分别为71%和15%，支原体感染组锌缺乏发生率高于对照组（X 2=6.71，P<0.01）。②支原体感染患儿急性期外周血CD3、CD4、CD4/CD8比值均低于健康对照组，CD8水平与对照组比较无差异（P＞0.05）。③支原体感染患儿急性期外周血免疫球蛋白IgG、IgM与对照组比较明显增高，补体C3水平低于对照组，差异有统计学意义（P<0.05）；而IgA、C4水平与对照组比较差异无统计学意义（P>0.05）。结论支原体感染儿童血清锌低于健康儿童水平，有较高的锌缺乏状况；同时伴有免疫功能紊乱，表现为淋巴细胞亚群水平失衡，T淋巴细胞增殖功能发生障碍和体液免疫受到损害。
目的：探討支原體感染兒童血清鋅水平與免疫功能變化。方法檢測38例支原體感染患兒和20例健康兒童血清鋅水平及免疫功能。結果①支原體感染組兒童血清鋅水平低于健康對照組水平，差異有統計學意義（P<0.01）。鋅缺乏在支原體感染組和對照組的暘性率分彆為71%和15%，支原體感染組鋅缺乏髮生率高于對照組（X 2=6.71，P<0.01）。②支原體感染患兒急性期外週血CD3、CD4、CD4/CD8比值均低于健康對照組，CD8水平與對照組比較無差異（P＞0.05）。③支原體感染患兒急性期外週血免疫毬蛋白IgG、IgM與對照組比較明顯增高，補體C3水平低于對照組，差異有統計學意義（P<0.05）；而IgA、C4水平與對照組比較差異無統計學意義（P>0.05）。結論支原體感染兒童血清鋅低于健康兒童水平，有較高的鋅缺乏狀況；同時伴有免疫功能紊亂，錶現為淋巴細胞亞群水平失衡，T淋巴細胞增殖功能髮生障礙和體液免疫受到損害。
목적：탐토지원체감염인동혈청자수평여면역공능변화。방법검측38례지원체감염환인화20례건강인동혈청자수평급면역공능。결과①지원체감염조인동혈청자수평저우건강대조조수평，차이유통계학의의（P<0.01）。자결핍재지원체감염조화대조조적양성솔분별위71%화15%，지원체감염조자결핍발생솔고우대조조（X 2=6.71，P<0.01）。②지원체감염환인급성기외주혈CD3、CD4、CD4/CD8비치균저우건강대조조，CD8수평여대조조비교무차이（P＞0.05）。③지원체감염환인급성기외주혈면역구단백IgG、IgM여대조조비교명현증고，보체C3수평저우대조조，차이유통계학의의（P<0.05）；이IgA、C4수평여대조조비교차이무통계학의의（P>0.05）。결론지원체감염인동혈청자저우건강인동수평，유교고적자결핍상황；동시반유면역공능문란，표현위림파세포아군수평실형，T림파세포증식공능발생장애화체액면역수도손해。
Objective To research the changes of serum zinc level and immune function in children infected with MP. Methods The levels of zinc in serum and T lymphocyte subsets were measured in 38 children infected with MP and 20 samples from healthy children as controls. Result ①The value of serum zinc of children infected with MP were significantly lower than those of the normal controls (P<0.01). The positive rate of zinc deficiency in children infected with MP were 71%and 15%in controls.. The prevalence of zinc deficiency in children infected with MP was statistically higher than controls group.(X2=6.71, P<0.01).②Among the children infected with MP, the levels of CD3、CD4、CD4/CD8 were significantly lower than those in control group, the levels of CD8 had no difference (P>0.05).③The value of serum IgG、IgM of children infected with MP were obviously higher than those in controls group. And C3 were lower than those in controls, (P<0. 05), There were no no differences of IgA and C4 between children infected with MP and control groups (P>0.05). Conclusion The results suggested that serum zinc level decreased in chilren infected with MP accompanying with the imbalance of cellular immunity and the damage of humoral immunity.
