泰山医学院学报
泰山醫學院學報
태산의학원학보
Journal of Taishan Medical College
2015年
9期
978-981
,共4页
体素内非相干运动%扩散加权成像%骨骼肌
體素內非相榦運動%擴散加權成像%骨骼肌
체소내비상간운동%확산가권성상%골격기
intravoxel incoherent motion%diffusion-weighted imaging%skeletal muscle
目的:旨在探究以IVIM加权成像无创性评价骨骼肌静息状态及运动后其灌注功能、扩散功能的改变情况。方法15名健康志愿者,在静息状态下对其前臂行IVIM序列扫描,然后于标准化手柄运动后立即行IVIM扫描。将扫描图像传入工作站,于指浅/深屈肌、肱桡肌及桡侧腕长伸肌选取感兴趣区( ROI),分别重复计算各肌肉运动前后的弥散系数( D)、假扩散系数( D*)及灌注分数( Fp),并得到各参数的伪彩图。不同肌群组各数据的差异及不同时间点同组肌群各数据的差异使用重复测量方差分析,统计各差异是否有统计学意义。结果静息状态下的各参数值如下:D*为(28.4±11.0)×10-3 mm2/s,Fp为0.03±0.01,D为(1.45±0.08)×10-3 mm2/s;运动后各IVIM参数发生明显变化,在指浅/深屈肌(FDS/FDP),D*增加279±225%(P﹤0.029),Fp增加136±55%(P﹤0.01),D增加18±9%( P﹤0.01)。肱桡肌的各IVIM参数同样有相应的增高,但程度低于FDS/FDP。20 min后, FDS/FDP各IVIM参数仍处于高值状态,但是肱桡肌各IVIM参数与静息状态下相比无明显差异。结论 IVIM扩散加权成像可以同时无创性的提供肌肉静息状态及运动后其灌注及弥散功能的变化情况,为应用于类似周围血管闭塞等与肌肉血流灌注相关的疾病提供可能。
目的:旨在探究以IVIM加權成像無創性評價骨骼肌靜息狀態及運動後其灌註功能、擴散功能的改變情況。方法15名健康誌願者,在靜息狀態下對其前臂行IVIM序列掃描,然後于標準化手柄運動後立即行IVIM掃描。將掃描圖像傳入工作站,于指淺/深屈肌、肱橈肌及橈側腕長伸肌選取感興趣區( ROI),分彆重複計算各肌肉運動前後的瀰散繫數( D)、假擴散繫數( D*)及灌註分數( Fp),併得到各參數的偽綵圖。不同肌群組各數據的差異及不同時間點同組肌群各數據的差異使用重複測量方差分析,統計各差異是否有統計學意義。結果靜息狀態下的各參數值如下:D*為(28.4±11.0)×10-3 mm2/s,Fp為0.03±0.01,D為(1.45±0.08)×10-3 mm2/s;運動後各IVIM參數髮生明顯變化,在指淺/深屈肌(FDS/FDP),D*增加279±225%(P﹤0.029),Fp增加136±55%(P﹤0.01),D增加18±9%( P﹤0.01)。肱橈肌的各IVIM參數同樣有相應的增高,但程度低于FDS/FDP。20 min後, FDS/FDP各IVIM參數仍處于高值狀態,但是肱橈肌各IVIM參數與靜息狀態下相比無明顯差異。結論 IVIM擴散加權成像可以同時無創性的提供肌肉靜息狀態及運動後其灌註及瀰散功能的變化情況,為應用于類似週圍血管閉塞等與肌肉血流灌註相關的疾病提供可能。
목적:지재탐구이IVIM가권성상무창성평개골격기정식상태급운동후기관주공능、확산공능적개변정황。방법15명건강지원자,재정식상태하대기전비행IVIM서렬소묘,연후우표준화수병운동후립즉행IVIM소묘。장소묘도상전입공작참,우지천/심굴기、굉뇨기급뇨측완장신기선취감흥취구( ROI),분별중복계산각기육운동전후적미산계수( D)、가확산계수( D*)급관주분수( Fp),병득도각삼수적위채도。불동기군조각수거적차이급불동시간점동조기군각수거적차이사용중복측량방차분석,통계각차이시부유통계학의의。결과정식상태하적각삼수치여하:D*위(28.4±11.0)×10-3 mm2/s,Fp위0.03±0.01,D위(1.45±0.08)×10-3 mm2/s;운동후각IVIM삼수발생명현변화,재지천/심굴기(FDS/FDP),D*증가279±225%(P﹤0.029),Fp증가136±55%(P﹤0.01),D증가18±9%( P﹤0.01)。굉뇨기적각IVIM삼수동양유상응적증고,단정도저우FDS/FDP。20 min후, FDS/FDP각IVIM삼수잉처우고치상태,단시굉뇨기각IVIM삼수여정식상태하상비무명현차이。결론 IVIM확산가권성상가이동시무창성적제공기육정식상태급운동후기관주급미산공능적변화정황,위응용우유사주위혈관폐새등여기육혈류관주상관적질병제공가능。
Objective:The purpose of this work was to evaluate the feasibility of intravoxel incoherent motion imaging ( IVIM)for quantification of perfusion and diffusion effects noninvasivly in skeletal muscle at rest and following exercise. Methods:Fifteen healthy volunteers underwent diffusion-weighted MRI of the forearm at rest,then,after a standardized handgrip exercise,dynamic images were acquired. Diffusion( D)and pseudodiffusion( D*)coefficients as well as the per-fusion fraction( Fp)were measured in regions of interest in different skeletal muscle by using the workstation,with paramet-rical maps produced. Differences in D,D*,and FP between muscle groups and between time points were calculated using a repeated measures analysis of variance with post hoc Bonferroni tests. Results:Mean values and standard deviations at rest were the following:D*(28. 4 ± 11. 0)× 10-3 mm2/s,Fp(0. 03 ± 0. 01),D(1. 45 ± 0. 08)× 10-3 mm2/s;three param-eters changed after exercising:In the FDS/FDP,D* increased by(279 ±225%)(P﹤0.029),Fp by(136 ±55%)(P﹤0. 01),and D by(18 ± 9%)(P﹤0. 01). A significant increase of IVIM parameters could also be detected in the bra-chioradialis muscle,which however was significantly lower than in the FDS/FDP. After 20 min,all parameters were still significantly elevated in the FDS/FDP but not in the brachioradialis muscle compared with the resting state. Conclusion:The IVIM approach allows simultaneous quantification of muscle perfusion and diffusion effects at rest and following exercise, thus,it is possibile to be used in perfusion-related muscle diseases,such as peripheral arterial occlusive disease.