CAJ | 학술논문

目的：通过观察盐酸青藤碱不同剂量关节腔注射治疗髋骨性关节炎的临床疗效及不良反应，探讨盐酸青藤碱治疗髋骨性关节炎的量效关系。方法：将132例门诊和住院的髋骨性关节炎患者随机分成治疗组和对照组。治疗组给予盐酸青藤碱注射液35mg关节腔内注射，每日1次，每10天为一疗程。对照组给予盐酸青藤碱注射液25mg关节腔内注射，每日1次，每10天为一疗程。结果：治疗组总有效率优于对照组（P＜0.05），不良反应两组无差别。结论：盐酸青藤碱关节腔注射治疗髋骨性关节炎存在量效关系，35mg关节腔注射疗效明显优于25mg，不良反应无明显增加。
목적：통과관찰염산청등감불동제량관절강주사치료관골성관절염적림상료효급불량반응，탐토염산청등감치료관골성관절염적량효관계。방법：장132례문진화주원적관골성관절염환자수궤분성치료조화대조조。치료조급여염산청등감주사액35mg관절강내주사，매일1차，매10천위일료정。대조조급여염산청등감주사액25mg관절강내주사，매일1차，매10천위일료정。결과：치료조총유효솔우우대조조（P＜0.05），불량반응량조무차별。결론：염산청등감관절강주사치료관골성관절염존재량효관계，35mg관절강주사료효명현우우25mg，불량반응무명현증가。
Objective:By looking at different sinomenine hydrochloride dose intra-articular injection in the treatment for hip arthritis clinical curative effect and adverse reactions of sinomenine hydrochloride treatment for hip arthritis, and the dose-effect relationship. Methods:132 cases of outpatient and hospitalization hip arthritis patients were randomly divided into treatment group and control group. Treatment group given hydrochloride sinomenine injection 35mg intra-articular injection, once a day, every 10 days for a course of treatment. Patients in the control group were given hydrochloride sinomenine injection 25mg intra-articular injection, once a day, every 10 days for a course of treatment. Results: The total effective rate in the treatment group was better than that in the control group (P<0.05), and there were no differences in adverse reactions between the two groups. Conclusion: Hydrochloride sinomenine intra-articular <br> injection in the treatment of hip joint inflammation in the presence of dose effect relationship, 35mg articular cavity injection curative effect is obviously superior to 25mg, no significant increase in adverse reactions.