国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
International Journal of Pediatrics
2015年
5期
519-523
,共5页
哮喘%表观遗传学%DNA甲基化%组蛋白修饰%微小核糖核酸
哮喘%錶觀遺傳學%DNA甲基化%組蛋白脩飾%微小覈糖覈痠
효천%표관유전학%DNA갑기화%조단백수식%미소핵당핵산
Asthma%Epigenetics%DNA methylation%Histone modification%miRNA
哮喘是一种气道慢性炎症性疾病,遗传因素及环境因素共同参与其发病.一方面,哮喘与遗传因素密切相关;另一方面,饮食摄入、烟雾暴露、空气污染等外界因素均与其发病相关.新近研究发现,表观遗传学在哮喘发生发展中发挥重要的作用,遗传及环境因素均可影响表观遗传学修饰.因此,该文对哮喘表观遗传学调控及哮喘表观遗传学治疗等方面研究进展加以综述.
哮喘是一種氣道慢性炎癥性疾病,遺傳因素及環境因素共同參與其髮病.一方麵,哮喘與遺傳因素密切相關;另一方麵,飲食攝入、煙霧暴露、空氣汙染等外界因素均與其髮病相關.新近研究髮現,錶觀遺傳學在哮喘髮生髮展中髮揮重要的作用,遺傳及環境因素均可影響錶觀遺傳學脩飾.因此,該文對哮喘錶觀遺傳學調控及哮喘錶觀遺傳學治療等方麵研究進展加以綜述.
효천시일충기도만성염증성질병,유전인소급배경인소공동삼여기발병.일방면,효천여유전인소밀절상관;령일방면,음식섭입、연무폭로、공기오염등외계인소균여기발병상관.신근연구발현,표관유전학재효천발생발전중발휘중요적작용,유전급배경인소균가영향표관유전학수식.인차,해문대효천표관유전학조공급효천표관유전학치료등방면연구진전가이종술.
Asthma is a chronic airway inflammatory disease,which is caused by both genetic and environmental factors.For one thing, asthma is associated with genetic factors;for another thing, many exogenous triggering factors,such as diatery intake, smoke exposure and air pollution can impact on the development of asthma.Recently,many studies have showed that epigenetic changes which are influenced by the both factors play an important role in the pathophysiology of asthma.This article reviews the update advances about the epigenetic regulation and epigenetic therapy in asthma.
