现代肿瘤医学
現代腫瘤醫學
현대종류의학
Journal of Modern Oncology
2015年
21期
3207-3210
,共4页
磷脂酶( PLCE1 )%肿瘤%信号通路%预后
燐脂酶( PLCE1 )%腫瘤%信號通路%預後
린지매( PLCE1 )%종류%신호통로%예후
PLCE1%tumor%signaling pathway%prognosis
磷脂酶 Cε1（phospholipase C epsilon-1，PLCE1）是新近发现的磷脂酶C家族的一种同工酶。PLCE1是一种癌基因，在多种肿瘤中高表达，参与调节细胞的生长、分化、细胞凋亡及血管生成，且与肿瘤的不良预后有关。PLCE1能激活 IP3/Ca2+、DG/PKC、ERK和 MAPK 等重要信号通路，通过激活上游基因和改变下游基因的表达调控细胞的生理和病理过程。研究发现，PLCE1对于恶性肿瘤的诊断和预后的判断具有重要的参考价值，其有望成为肿瘤预后评估的重要指标和基因治疗的新靶点。
燐脂酶 Cε1（phospholipase C epsilon-1，PLCE1）是新近髮現的燐脂酶C傢族的一種同工酶。PLCE1是一種癌基因，在多種腫瘤中高錶達，參與調節細胞的生長、分化、細胞凋亡及血管生成，且與腫瘤的不良預後有關。PLCE1能激活 IP3/Ca2+、DG/PKC、ERK和 MAPK 等重要信號通路，通過激活上遊基因和改變下遊基因的錶達調控細胞的生理和病理過程。研究髮現，PLCE1對于噁性腫瘤的診斷和預後的判斷具有重要的參攷價值，其有望成為腫瘤預後評估的重要指標和基因治療的新靶點。
린지매 Cε1（phospholipase C epsilon-1，PLCE1）시신근발현적린지매C가족적일충동공매。PLCE1시일충암기인，재다충종류중고표체，삼여조절세포적생장、분화、세포조망급혈관생성，차여종류적불량예후유관。PLCE1능격활 IP3/Ca2+、DG/PKC、ERK화 MAPK 등중요신호통로，통과격활상유기인화개변하유기인적표체조공세포적생리화병리과정。연구발현，PLCE1대우악성종류적진단화예후적판단구유중요적삼고개치，기유망성위종류예후평고적중요지표화기인치료적신파점。
Objectives:PLCE1 is a recently found member of PLC family. It has been proved to be an oncogene. PLCE1 has been reported that it is hightly expressed in various types of human cancer,and taKe part in cellular growth,differentiation,cellular apoptosis and formation of the blood vessels,and it is negatively correlated with progno-sis. PLCE1 over-expression activates the IP3/Ca2+,DG/PKC,ERK and MAPK signaling pathways in several crucial aspects of the molecular mechanism. PLCE1 plays an important role in the regulation of physiological and pathological process in tumor. Based on the research findings,PLCE1 has important reference value for diagnosis and prognosis predicting of malignant tumor,and it represents a viable potential target for the prognostic judgement and the therapy of tumor.
