现代诊断与治疗
現代診斷與治療
현대진단여치료
Modern Diagnosis & Treatment
2015年
17期
3843-3845
,共3页
依那普利%丹参酮%急性加重期%肺心病
依那普利%丹參酮%急性加重期%肺心病
의나보리%단삼동%급성가중기%폐심병
Enalapril%Tanshinone%Pulmonary Heart Disease%Acute Exacerbation
目的：研究依那普利联合丹参酮治疗急性加重期肺心病的临床疗效及对患者预后的影响。方法将我院收治的100例急性加重期肺心病患者抽签随机分为观察组和对照组各50例，对照组单一采用依那普利治疗，观察组采取依那普利联合丹参酮治疗。比较两组临床疗效、血液流变学及心功能指标变化。结果观察组治疗总有效率为94．0%，显著高于对照组的78．0%，两组比较有统计学意义（P<0．05）；治疗后观察组血浆黏度、红细胞压积、红细胞计数、纤维蛋白原显著降低，与对照组比较差异有统计学意义（P<0．05）；治疗后观察组LVEF、SV、CO分别为62．64±6．54%、70．69±6．82ml、4．82±0．62L/min，高于对照组的57．69±5．24%、54．36±7．21ml、4．02±1．25L/min，对比差异显著，有统计学意义（P<0．05）；两组均未见明显不良反应发生。结论依那普利联合丹参酮治疗急性加重期肺心病效果显著，可改善患者心功能，且安全性较高，具有较高的临床应用价值。
目的：研究依那普利聯閤丹參酮治療急性加重期肺心病的臨床療效及對患者預後的影響。方法將我院收治的100例急性加重期肺心病患者抽籤隨機分為觀察組和對照組各50例，對照組單一採用依那普利治療，觀察組採取依那普利聯閤丹參酮治療。比較兩組臨床療效、血液流變學及心功能指標變化。結果觀察組治療總有效率為94．0%，顯著高于對照組的78．0%，兩組比較有統計學意義（P<0．05）；治療後觀察組血漿黏度、紅細胞壓積、紅細胞計數、纖維蛋白原顯著降低，與對照組比較差異有統計學意義（P<0．05）；治療後觀察組LVEF、SV、CO分彆為62．64±6．54%、70．69±6．82ml、4．82±0．62L/min，高于對照組的57．69±5．24%、54．36±7．21ml、4．02±1．25L/min，對比差異顯著，有統計學意義（P<0．05）；兩組均未見明顯不良反應髮生。結論依那普利聯閤丹參酮治療急性加重期肺心病效果顯著，可改善患者心功能，且安全性較高，具有較高的臨床應用價值。
목적：연구의나보리연합단삼동치료급성가중기폐심병적림상료효급대환자예후적영향。방법장아원수치적100례급성가중기폐심병환자추첨수궤분위관찰조화대조조각50례，대조조단일채용의나보리치료，관찰조채취의나보리연합단삼동치료。비교량조림상료효、혈액류변학급심공능지표변화。결과관찰조치료총유효솔위94．0%，현저고우대조조적78．0%，량조비교유통계학의의（P<0．05）；치료후관찰조혈장점도、홍세포압적、홍세포계수、섬유단백원현저강저，여대조조비교차이유통계학의의（P<0．05）；치료후관찰조LVEF、SV、CO분별위62．64±6．54%、70．69±6．82ml、4．82±0．62L/min，고우대조조적57．69±5．24%、54．36±7．21ml、4．02±1．25L/min，대비차이현저，유통계학의의（P<0．05）；량조균미견명현불량반응발생。결론의나보리연합단삼동치료급성가중기폐심병효과현저，가개선환자심공능，차안전성교고，구유교고적림상응용개치。
Objective To study the clinical therapeutic effects of enalapril combined with tanshi-none in the treatment of pulmonary heart disease in acute exacerbation and the influence on prognosis of the patients. Methods 100 patients were randomly divided into the observation group <br> (50cases) and the control group (50 cases). The control group were treated with single enalapril while the observation group with enalapril combined with tanshinone. The clinical efficacy, hemorheology and cardiac function of the two groups were compared. Results The total effective rate of the observation group was 94% which was significantly higher than 78% of the control group(P<0.05); After the treatment, the plasma viscosity, hematocrit, red blood cell count and fib-rinogen decreased significantly and were significantly lower than those of the control group (P <0.05); after the treatment, the LVEF, SV and CO of the observation group were (62.64 ±6.54)%, (70.69±6.82)ml and(4.82±0.62)L/min which was significantly higher than(57.69±5.24)%,(54.36±7.21) ml and(4.02±1.25)L/min of the control group and the difference was significant(P<0.05); there were no obvious adverse reactions in both two groups. Conclusion The effect of enalapril combined with tanshinone in treatment of pulmonary heart disease in acute exacerbation is remarkable. The treatment can improve the patients' cardiac function and is of high safety and high clinical appli-cation value.
