CAJ | 학술논문

目的：评价癌胚抗原(CEA)、细胞角蛋白19片段（CYFRA21-1）、糖类抗原CA-125、CA-242、神经原特异性烯醇化酶(NSE)五种肿瘤标志物在肺癌早期诊断中的临床价值。方法回顾性分析708例住院病人5项血清肿瘤标志物水平和临床病理资料。结果肺癌5种血清肿瘤标志物阳性检出率明显高于与肺良性疾病,差异有统计学意义（P<0．05）；鳞癌、腺癌、小细胞癌阳性检出率分别是CYFRA21-1、（CEA、CA-242）、NSE最高，相比其他标志物均有统计学意义（P<0．05）。腺癌CEA、CA-125、CA-242肿瘤标志物水平明显高于鳞癌、小细胞肺癌(P<0．05)，鳞癌CYFRA21-1水平明显高于腺癌、小细胞肺癌(P<0．05)；小细胞肺癌NSE水平明显高于腺癌、鳞癌（P<0．05）。肿瘤标志物水平与肺癌临床分期相关,标志物水平越高,分期越晚。结论 CEA、CYFRA21-1、CA-125、CA-242及NSE仍是诊断肺癌的重要肿瘤标志物,鳞癌、腺癌、小细胞肺癌的实验室诊断可分别优先选择CYFRA21-1,CEA、CA-242,NSE。
목적：평개암배항원(CEA)、세포각단백19편단（CYFRA21-1）、당류항원CA-125、CA-242、신경원특이성희순화매(NSE)오충종류표지물재폐암조기진단중적림상개치。방법회고성분석708례주원병인5항혈청종류표지물수평화림상병리자료。결과폐암5충혈청종류표지물양성검출솔명현고우여폐량성질병,차이유통계학의의（P<0．05）；린암、선암、소세포암양성검출솔분별시CYFRA21-1、（CEA、CA-242）、NSE최고，상비기타표지물균유통계학의의（P<0．05）。선암CEA、CA-125、CA-242종류표지물수평명현고우린암、소세포폐암(P<0．05)，린암CYFRA21-1수평명현고우선암、소세포폐암(P<0．05)；소세포폐암NSE수평명현고우선암、린암（P<0．05）。종류표지물수평여폐암림상분기상관,표지물수평월고,분기월만。결론 CEA、CYFRA21-1、CA-125、CA-242급NSE잉시진단폐암적중요종류표지물,린암、선암、소세포폐암적실험실진단가분별우선선택CYFRA21-1,CEA、CA-242,NSE。
Objective To evaluate the clinical value of 19 tumor markers in the early diagnosis of lung cancer by evaluating the five kinds of tumor markers(CEA),CYFRA21-1,CA-125 ,CA-242 and NSE. Methods Retrospective analysis of 708 cases of hospitalized patients with 5 serum tumor markers level and clinical pathology data.Results The positive detection rate of 5 serum tumor markers in lung cancer was significantly higher than that in benign lung disease (P<0.05). The positive rate of squamous cell carcinoma, adenocarcinoma, small cell carcinoma was CYFRA21-1, (CEA,CA-242)and NSE was the highest, compared with other markers(P<0.05). The levels of CEA, CA-125 and CA-242 were significantly higher than those of squamous cell carcinoma and small cell lung cancer (P<0.05), and the level of CYFRA21-1 was significantly higher than that of ade-nocarcinoma and small cell lung cancer (P<0.05). The level of NSE in small cell lung cancer was significantly higher than that of adenocarcinoma and squamous cell carcinoma (P<0.05). Tumor markers were associated with clinical stages of lung cancer, and the higher the level of markers, the later stage of staging.Conclusions CEA,CYFRA21-1,CA-242,NSE and CA-125 were still im-portant tumor markers in diagnosis of lung cancer, the laboratory diagnosis of squamous cell car-cinoma, adenocarcinoma, small cell lung cancer, CYFRA21-1,CEA,CA-242,NSE.