国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
International Journal of Pediatrics
2015年
5期
499-502,506
,共5页
P糖蛋白%白血病%多药耐药
P糖蛋白%白血病%多藥耐藥
P당단백%백혈병%다약내약
P-glycoprotein%Leukemia%Multi-drug resistance
多药耐药(multidrug resistance,MDR)是导致白血病化疗失败的主要原因,白血病MDR的产生与细胞膜表面P糖蛋白(P-glycoprotein,P-gp)的药物转运作用直接相关,多种信号传导通路如MAPKs、NF-κB、Hedgehog、Wnt/β-catenin、PI3K/Akt参与调节P-gp的表达,而调控因子Stats、microRNA、TRAIL、HDACs也与P-gp的表达密切相关.该文就白血病MDR细胞中P-gp的表达调控机制的研究进展作一综述.
多藥耐藥(multidrug resistance,MDR)是導緻白血病化療失敗的主要原因,白血病MDR的產生與細胞膜錶麵P糖蛋白(P-glycoprotein,P-gp)的藥物轉運作用直接相關,多種信號傳導通路如MAPKs、NF-κB、Hedgehog、Wnt/β-catenin、PI3K/Akt參與調節P-gp的錶達,而調控因子Stats、microRNA、TRAIL、HDACs也與P-gp的錶達密切相關.該文就白血病MDR細胞中P-gp的錶達調控機製的研究進展作一綜述.
다약내약(multidrug resistance,MDR)시도치백혈병화료실패적주요원인,백혈병MDR적산생여세포막표면P당단백(P-glycoprotein,P-gp)적약물전운작용직접상관,다충신호전도통로여MAPKs、NF-κB、Hedgehog、Wnt/β-catenin、PI3K/Akt삼여조절P-gp적표체,이조공인자Stats、microRNA、TRAIL、HDACs야여P-gp적표체밀절상관.해문취백혈병MDR세포중P-gp적표체조공궤제적연구진전작일종술.
Multidrug resistance (MDR)has been a main reason for the failure of leukemia chemotherapy.The generation of MDR in leukemia is directly related to the transportation of drug efflux of P-glycoprotein (P-gp)on cell membrane surface.Many signaling pathways such as MAPK、NF-κB、Hedgehog、Wnt/β-catenin、 and PI3K/Akt involves in regulating of P-gp expression.Meanwhile, regulation factors including Stats、 microR-NA、TRAIL and HDACs are closely related to the P-gp expression.This review briefly discusses the progress of the regulatory mechanisms of P-gp in MDR of leukemia.
