国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
International Journal of Pediatrics
2015年
5期
488-491
,共4页
去整合素金属蛋白酶10%泌尿系统
去整閤素金屬蛋白酶10%泌尿繫統
거정합소금속단백매10%비뇨계통
A disintegrin and metalloproteinase 10%Urinary tract
去整合素金属蛋白酶10(ADAM10)是一种锌依赖的多结构域Ⅰ型跨膜蛋白,在进化中高度保守,可介导多种分子成熟以及跨膜分子胞外功能区脱落,具有蛋白水解、细胞黏附、细胞融合及信号传递等功能.该文就其结构和功能、作用底物和相关信号通路、影响其表达和催化活性的因素、在泌尿系统疾病中的研究进展进行综述.
去整閤素金屬蛋白酶10(ADAM10)是一種鋅依賴的多結構域Ⅰ型跨膜蛋白,在進化中高度保守,可介導多種分子成熟以及跨膜分子胞外功能區脫落,具有蛋白水解、細胞黏附、細胞融閤及信號傳遞等功能.該文就其結構和功能、作用底物和相關信號通路、影響其錶達和催化活性的因素、在泌尿繫統疾病中的研究進展進行綜述.
거정합소금속단백매10(ADAM10)시일충자의뢰적다결구역Ⅰ형과막단백,재진화중고도보수,가개도다충분자성숙이급과막분자포외공능구탈락,구유단백수해、세포점부、세포융합급신호전체등공능.해문취기결구화공능、작용저물화상관신호통로、영향기표체화최화활성적인소、재비뇨계통질병중적연구진전진행종술.
A disintegrin and metalloproteinase 10 is a zinc dependent transmembrane type Ⅰ multi-domain of protein which is highly conserved in evolution and mediates protein maturation and ectodomain shedding, with protein hydrolysis, cellular adhesion, cellular fusion and signal transmission.This article reviews its structure and function, the substrate and relative signaling pathways, the factors influencing its expression and catalytic activity,the research progress in urinary tract diseases.
