CAJ | 학술논문

脓毒症是由病原微生物感染所致的全身炎性反应综合征.因其高发病率、高病死率及高医疗费用已引起全球关注,脓毒症成为儿科重症医学的临床研究热点.大量研究表明严重脓毒症多器官功能障碍综合征的发生与线粒体呼吸链功能障碍密切相关.组织器官氧化磷酸化功能障碍是脓毒症器官功能障碍的重要特征之一.该文就脓毒症线粒体呼吸链功能障碍的研究进展作一综述.
농독증시유병원미생물감염소치적전신염성반응종합정.인기고발병솔、고병사솔급고의료비용이인기전구관주,농독증성위인과중증의학적림상연구열점.대량연구표명엄중농독증다기관공능장애종합정적발생여선립체호흡련공능장애밀절상관.조직기관양화린산화공능장애시농독증기관공능장애적중요특정지일.해문취농독증선립체호흡련공능장애적연구진전작일종술.
Sepsis is a complicated pathophysiological disorder arising from a systemic inflammatory response to infection.Because of high morbidity,high mortality and high cost of treatment, sepsis has caused global attention and become a hot spot in pediatric intensive medical research.Increasing number of studies have shown a close correlation between the occurrence of multiple organ dysfunction syndrome and mitochondrial dysfunction in sepsis.A major feature in sepsis is dysfunction of mitochondrial oxidative phosphorylation.This review discusses the dysfunction of mitochondrial respiratory chain in sepsis.