海军医学杂志
海軍醫學雜誌
해군의학잡지
Journal of Navy Medicine
2015年
5期
419-420,469
,共3页
细胞免疫功能%腹腔镜%结肠肿瘤%全肠系膜切除
細胞免疫功能%腹腔鏡%結腸腫瘤%全腸繫膜切除
세포면역공능%복강경%결장종류%전장계막절제
Cell immune function%Laparoscopy%Colorectal neoplasm%Full mesenterectomy
目的 比较腹腔镜与开腹2种不同的手术方式对于行右半结肠癌根治术患者的免疫功能的影响. 方法 采取回顾性研究方法,将2012年1月到2014年10月的100名符合入组要求的患者根据手术方法的不同分为腹腔镜组50例,开腹组50例,比较2组患者的手术前后C反应蛋白( CRP)、白细胞( WBC)、白细胞介素( IL)-6、CD4 +、CD8 +、CD4 +/CD8 +、NK细胞、淋巴细胞数(Lymph)的变化. 结果 与手术前比较,腹腔镜组WBC、CRP、IL-6升高,差异有统计学意义(P<0.05),开腹组WBC、Lymph 、CRP、IL-6升高差异有统计学意义(P<0.05). 手术后腹腔镜组与开腹组比较CRP、IL-6、CD4 +、CD8+差异有统计学意义(P<0.05). 腹腔镜组与开腹组腹腔引流液WBC、IL-6比较差异有统计学意义(P<0.05). 结论 只要严格掌握手术适应征,腹腔镜右半结肠根治术可以达到同常规开腹手术相同的根治效果,且对机体免疫功能影响较小,可以在临床推广.
目的 比較腹腔鏡與開腹2種不同的手術方式對于行右半結腸癌根治術患者的免疫功能的影響. 方法 採取迴顧性研究方法,將2012年1月到2014年10月的100名符閤入組要求的患者根據手術方法的不同分為腹腔鏡組50例,開腹組50例,比較2組患者的手術前後C反應蛋白( CRP)、白細胞( WBC)、白細胞介素( IL)-6、CD4 +、CD8 +、CD4 +/CD8 +、NK細胞、淋巴細胞數(Lymph)的變化. 結果 與手術前比較,腹腔鏡組WBC、CRP、IL-6升高,差異有統計學意義(P<0.05),開腹組WBC、Lymph 、CRP、IL-6升高差異有統計學意義(P<0.05). 手術後腹腔鏡組與開腹組比較CRP、IL-6、CD4 +、CD8+差異有統計學意義(P<0.05). 腹腔鏡組與開腹組腹腔引流液WBC、IL-6比較差異有統計學意義(P<0.05). 結論 隻要嚴格掌握手術適應徵,腹腔鏡右半結腸根治術可以達到同常規開腹手術相同的根治效果,且對機體免疫功能影響較小,可以在臨床推廣.
목적 비교복강경여개복2충불동적수술방식대우행우반결장암근치술환자적면역공능적영향. 방법 채취회고성연구방법,장2012년1월도2014년10월적100명부합입조요구적환자근거수술방법적불동분위복강경조50례,개복조50례,비교2조환자적수술전후C반응단백( CRP)、백세포( WBC)、백세포개소( IL)-6、CD4 +、CD8 +、CD4 +/CD8 +、NK세포、림파세포수(Lymph)적변화. 결과 여수술전비교,복강경조WBC、CRP、IL-6승고,차이유통계학의의(P<0.05),개복조WBC、Lymph 、CRP、IL-6승고차이유통계학의의(P<0.05). 수술후복강경조여개복조비교CRP、IL-6、CD4 +、CD8+차이유통계학의의(P<0.05). 복강경조여개복조복강인류액WBC、IL-6비교차이유통계학의의(P<0.05). 결론 지요엄격장악수술괄응정,복강경우반결장근치술가이체도동상규개복수술상동적근치효과,차대궤체면역공능영향교소,가이재림상추엄.
Objective To compare the effects of right colon cancer radical operation by laparoscopy and laparotomy on the immune system of the patients.Methods A retrospective study was made on the 100 patients admitted into the hospital from January, 2012 to October, 2014.According to different surgical methods, the patients were divided into the laparoscopic group and the laparoto-my group, each consisting of 50 patients.Levels of C reactive protein (CRP), white blood cell (WBC), interleukin (IL-6), CD4 +/CD8 +, NK, and lymphocyte were compared between the patients of the 2 groups after surgery.Results As compared with those before surgery, the levels of WBC, CRP and IL-6 of the laparoscopic group were increased, with statistical significance (P<0.05).As com-pared with those before surgery, the levels of WBC, Lymph, CRP and IL-6 of the laparotomy group were elevated, also with statistical significance (P<0.05).There was statistical significance in the levels of CRP, IL-6, CD4 +, CD8 +, when comparisons were made between the 2 groups (P<0.05).There was also statistical significance in the levels of WBC and IL-6 in peritoneal fluid, when com-parisons were made between the 2 groups (P<0.05).Conclusion So far as surgical indications were strictly taken into consideration, right colon cancer radical operation by laparoscopy could achieve identical treatment results as conventional laparotomy.Furthermore, it seemed to have less effect on the immune system, for this reason, it was worth further clinical application.
