海军医学杂志
海軍醫學雜誌
해군의학잡지
Journal of Navy Medicine
2015年
5期
434-437
,共4页
韦晓强%张征%沈若宇%张炜%徐尔理
韋曉彊%張徵%瀋若宇%張煒%徐爾理
위효강%장정%침약우%장위%서이리
同型半胱氨酸%2型糖尿病%血管病变
同型半胱氨痠%2型糖尿病%血管病變
동형반광안산%2형당뇨병%혈관병변
Homocysteine%Type 2 diabetes mellitus%Vascular pathologic change
目的 评价2型糖尿病患者颈动脉内膜中层厚度(MT)与血同型半胱氨酸(Hcy)的关系. 方法 检测127例初发2型糖尿病患者相关指标(体质量指数、血压、血脂及血糖) ,同时检测患者血Hcy与颈动脉MT,将所得结果与103例对照组进行比较. 所有2型糖尿病患者经治疗后随访测值再与治疗前比较. 结果 (1)2型糖尿病组患者治疗前三酰甘油及血Hcy高于对照组. 2型糖尿病组中Hcy升高者为32.3%(41/127),高于对照组的9.7%(10/103). 2型糖尿病组中,高Hcy者颈动脉MT[(0.98 ±0.20)mm]亦高于正常Hcy者[(0.88 ±0.16)mm]. (2)2型糖尿病患者经降糖、降压及调脂治疗后,颈动脉MT未见明显下降,高Hcy者颈动脉MT[(1.13 ±0.18)mm]仍高于正常Hcy者[(0.91 ±0.16)mm],多元逐步回归分析提示,2型糖尿病组血Hcy为影响颈动脉MT的独立相关因素. 结论 高同型半胱氨酸血症可能是2型糖尿病合并早期动脉粥样硬化的危险因素之一.
目的 評價2型糖尿病患者頸動脈內膜中層厚度(MT)與血同型半胱氨痠(Hcy)的關繫. 方法 檢測127例初髮2型糖尿病患者相關指標(體質量指數、血壓、血脂及血糖) ,同時檢測患者血Hcy與頸動脈MT,將所得結果與103例對照組進行比較. 所有2型糖尿病患者經治療後隨訪測值再與治療前比較. 結果 (1)2型糖尿病組患者治療前三酰甘油及血Hcy高于對照組. 2型糖尿病組中Hcy升高者為32.3%(41/127),高于對照組的9.7%(10/103). 2型糖尿病組中,高Hcy者頸動脈MT[(0.98 ±0.20)mm]亦高于正常Hcy者[(0.88 ±0.16)mm]. (2)2型糖尿病患者經降糖、降壓及調脂治療後,頸動脈MT未見明顯下降,高Hcy者頸動脈MT[(1.13 ±0.18)mm]仍高于正常Hcy者[(0.91 ±0.16)mm],多元逐步迴歸分析提示,2型糖尿病組血Hcy為影響頸動脈MT的獨立相關因素. 結論 高同型半胱氨痠血癥可能是2型糖尿病閤併早期動脈粥樣硬化的危險因素之一.
목적 평개2형당뇨병환자경동맥내막중층후도(MT)여혈동형반광안산(Hcy)적관계. 방법 검측127례초발2형당뇨병환자상관지표(체질량지수、혈압、혈지급혈당) ,동시검측환자혈Hcy여경동맥MT,장소득결과여103례대조조진행비교. 소유2형당뇨병환자경치료후수방측치재여치료전비교. 결과 (1)2형당뇨병조환자치료전삼선감유급혈Hcy고우대조조. 2형당뇨병조중Hcy승고자위32.3%(41/127),고우대조조적9.7%(10/103). 2형당뇨병조중,고Hcy자경동맥MT[(0.98 ±0.20)mm]역고우정상Hcy자[(0.88 ±0.16)mm]. (2)2형당뇨병환자경강당、강압급조지치료후,경동맥MT미견명현하강,고Hcy자경동맥MT[(1.13 ±0.18)mm]잉고우정상Hcy자[(0.91 ±0.16)mm],다원축보회귀분석제시,2형당뇨병조혈Hcy위영향경동맥MT적독립상관인소. 결론 고동형반광안산혈증가능시2형당뇨병합병조기동맥죽양경화적위험인소지일.
Objective To evaluate the relationship between carotid intima-media thickness ( MT) and plasma homocysteine ( Hcy) in type 2 diabetic patients.Methods Related indexes, such as body mass, blood pressure, blood lipid and blood sugar were evaluated in 127 patients with type 2 diabetes.At the same time, plasma homocysteine and carotid intima-media thickness were also measured.The obtained results were compared with those of the 103 controlled cases.After treatment, all the data detected during med-ical follow-ups were compared with those before treatment.Results (1) Before treatment, the triglyceride and Hcy levels of the type 2 diabetic patients were significantly higher than those of the control group.The elevated Hcy level in the patients with type 2 diabetes was 32.3%(41/127), which was obviously higher than 9.7%(10/103)of the control group.In the type 2 diabetic patients with high Hcy, MT was also higher than that of the patients with normal Hcy.(2) Following treatment, no significant reduction in carotid MT was seen in type 2 diabetic patients, and carotid MT in the patients with high Hcy was still higher than that of the patients with normal Hcy.Step-wise multiple regression analysis indicated that plasma Hcy concentration was a related independent factor influencing carotid MT of the type 2 diabetic patients.Conclusion Our study indicated that hyperhomosysteinemia might be one of the risk factors associated with early atherosclerosis in type 2 diabetic patients.
