国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
International Journal of Pediatrics
2015年
5期
563-566
,共4页
支气管肺炎%低分子肝素%异丙肾上腺素%雾化吸入%肺功能
支氣管肺炎%低分子肝素%異丙腎上腺素%霧化吸入%肺功能
지기관폐염%저분자간소%이병신상선소%무화흡입%폐공능
Bronchial pneumonia%Low molecular weight heparin%Isoproterenol%Inhalation%Pulmonary function
目的 观察并探讨低分子肝素联合异丙肾上腺素雾化吸入佐治小儿重症支气管肺炎的临床疗效.方法 收集2013年1月至2014年3月收治的110例患儿为研究对象并随机分为治疗组(57例)与对照组(53例),对照组给予抗感染、激素、祛痰、吸氧等对症治疗,并雾化吸入采用异丙肾上腺素,每日2次,治疗组在对照组基础上联合使用低分子肝素钠注射液雾化吸入,每日1次,治疗72 h后比较两组动脉血气指标,治疗5d后判定两组临床疗效.结果 治疗72h后,两组患儿肺功能、动脉血气指标及气道炎性均较治疗前明显改善;治疗组患儿PaO2、PaO2/FiO2显著高于对照组,而PaCO2、CRP则显著低于对照组,上述指标差异均有统计学意义(P＜0.05),治疗组喘憋、肺部罗音、咳嗽等消退时间明显低于对照组(P＜0.05).治疗5d后,治疗组治愈率(50.9％ vs.37.7％)、总体有效率(98.2％ vs.94.3％)均高于对照组,差异不具有统计学意义(P＞0.05).雾化吸入期间,两组一过性心率升高等不良反应发生率(10.5％vs.13.2)差异无统计学意义(x2=0.189,P=0.663).结论 在常规治疗小儿重症支气管肺炎基础上,联合应用低分子肝素与异丙肾上腺素雾化吸入能提高肺换气功能,减轻气道炎症,可在一定程度上提高临床疗效.
目的 觀察併探討低分子肝素聯閤異丙腎上腺素霧化吸入佐治小兒重癥支氣管肺炎的臨床療效.方法 收集2013年1月至2014年3月收治的110例患兒為研究對象併隨機分為治療組(57例)與對照組(53例),對照組給予抗感染、激素、祛痰、吸氧等對癥治療,併霧化吸入採用異丙腎上腺素,每日2次,治療組在對照組基礎上聯閤使用低分子肝素鈉註射液霧化吸入,每日1次,治療72 h後比較兩組動脈血氣指標,治療5d後判定兩組臨床療效.結果 治療72h後,兩組患兒肺功能、動脈血氣指標及氣道炎性均較治療前明顯改善;治療組患兒PaO2、PaO2/FiO2顯著高于對照組,而PaCO2、CRP則顯著低于對照組,上述指標差異均有統計學意義(P＜0.05),治療組喘憋、肺部囉音、咳嗽等消退時間明顯低于對照組(P＜0.05).治療5d後,治療組治愈率(50.9％ vs.37.7％)、總體有效率(98.2％ vs.94.3％)均高于對照組,差異不具有統計學意義(P＞0.05).霧化吸入期間,兩組一過性心率升高等不良反應髮生率(10.5％vs.13.2)差異無統計學意義(x2=0.189,P=0.663).結論 在常規治療小兒重癥支氣管肺炎基礎上,聯閤應用低分子肝素與異丙腎上腺素霧化吸入能提高肺換氣功能,減輕氣道炎癥,可在一定程度上提高臨床療效.
목적 관찰병탐토저분자간소연합이병신상선소무화흡입좌치소인중증지기관폐염적림상료효.방법 수집2013년1월지2014년3월수치적110례환인위연구대상병수궤분위치료조(57례)여대조조(53례),대조조급여항감염、격소、거담、흡양등대증치료,병무화흡입채용이병신상선소,매일2차,치료조재대조조기출상연합사용저분자간소납주사액무화흡입,매일1차,치료72 h후비교량조동맥혈기지표,치료5d후판정량조림상료효.결과 치료72h후,량조환인폐공능、동맥혈기지표급기도염성균교치료전명현개선;치료조환인PaO2、PaO2/FiO2현저고우대조조,이PaCO2、CRP칙현저저우대조조,상술지표차이균유통계학의의(P＜0.05),치료조천별、폐부라음、해수등소퇴시간명현저우대조조(P＜0.05).치료5d후,치료조치유솔(50.9％ vs.37.7％)、총체유효솔(98.2％ vs.94.3％)균고우대조조,차이불구유통계학의의(P＞0.05).무화흡입기간,량조일과성심솔승고등불량반응발생솔(10.5％vs.13.2)차이무통계학의의(x2=0.189,P=0.663).결론 재상규치료소인중증지기관폐염기출상,연합응용저분자간소여이병신상선소무화흡입능제고폐환기공능,감경기도염증,가재일정정도상제고림상료효.
Objective To explore clinical efficacy of low molecular weight heparin combined isoproterenol inhalation in treatment of children with severe bronchial pneumonia.Methods 110 patients from Jan 2013 to Apr 2014 were collected and randomly divided into treatment group (57 cases)and control group(53 cases), control group was given anti infection,hormone, expectorant, oxygen and other symptomatic treatment, besides, inhaled with isoprenaline, bid,based on which treatment group was inhalaled with low molecular weight heparin sodium injection, qd, arterial blood gas indexes were compared between 2 groups after 72 h treatment, and clinical efficacy were compared after 5 d treatment.Results After 72 h treatment,two groups of children with pulmonary function, arterial blood gas index and airway inflammatory improved obviously;treatment group with PaO2 and PaO2/FiO2 were significantly higher than control group, while PaCO2, CRP were significantly lower than control group, the differences of all above indexes were statistically significant (P ＜ 0.05).Treatment group with wheezing, pulmonary rales, cough disappeared time were significantly lower than control group (P ＜ 0.05).After 5d treatment,treatment group with cure rate (50.9％ vs.37.7％)and total effective rate (98.2％ vs.94.3％)were both higher than control group, the differences were not statistically significant (P ＞ 0.05) .During inhalation, two groups with incidences of temporary heart rate rise (10.5 ％ vs.13.2) had no significant difference (x2 =0.189 P =0.663).Conclusion Based on conventional treatment for children with severe pneumonia,low molecular weight heparin combined with isoproterenol inhalation can improve pulmonary ventilation function,reduce airway inflammation,and improve clinical efficacy to a certain extent.
