国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
International Journal of Pediatrics
2015年
5期
523-526
,共4页
哮喘%Toll样受体%气道重塑
哮喘%Toll樣受體%氣道重塑
효천%Toll양수체%기도중소
Asthma%TLR%Airway remodeling
支气管哮喘是儿童最常见的慢性呼吸系统疾病之一.气道重塑是哮喘病理变化的重要特征,也是哮喘症状难以控制的重要原因.Tol样受体(Toll-like receptor,TLR)是一种模式识别受体,表达于人呼吸道上皮细胞、平滑肌细胞、黏液腺细胞等多种气道壁结构细胞,在哮喘气道重塑中起重要的调节作用.该文就TLR在支气管哮喘气道重塑中的作用研究进展作一综述.
支氣管哮喘是兒童最常見的慢性呼吸繫統疾病之一.氣道重塑是哮喘病理變化的重要特徵,也是哮喘癥狀難以控製的重要原因.Tol樣受體(Toll-like receptor,TLR)是一種模式識彆受體,錶達于人呼吸道上皮細胞、平滑肌細胞、黏液腺細胞等多種氣道壁結構細胞,在哮喘氣道重塑中起重要的調節作用.該文就TLR在支氣管哮喘氣道重塑中的作用研究進展作一綜述.
지기관효천시인동최상견적만성호흡계통질병지일.기도중소시효천병리변화적중요특정,야시효천증상난이공제적중요원인.Tol양수체(Toll-like receptor,TLR)시일충모식식별수체,표체우인호흡도상피세포、평활기세포、점액선세포등다충기도벽결구세포,재효천기도중소중기중요적조절작용.해문취TLR재지기관효천기도중소중적작용연구진전작일종술.
Bronchial asthma is one of the most common chronic respiratory diseases in children.Airway remodeling that makes asthma difficult to control is an important pathological progress of asthma.Toll-like receptors (TLR), a kind of pattern recognition receptors, are expressed in a variety of human airway structure cells, such as airway epithelial cells, smooth muscle cells, mucus gland cells, etc.It is reported that TLRs play important roles in the regulation of airway remodeling in asthma.This article briefly summarizes the role of TLR in airway remodeling of asthma.
