CAJ | 학술논문

目的：观察顺铂胸腔灌注联合静脉吉西他滨或培美曲塞化疗治疗非小细胞肺癌并恶性胸水的临床疗效。方法：41例非小细胞肺癌并恶性胸水患者，顺铂按75mg/m2胸腔灌注，同时行常规剂量的静脉吉西他滨或培美曲塞化疗，评价肺部肿瘤和胸水的控制情况、生活质量及不良反应。结果：17例肺鳞癌患者中，胸水治疗RR 76.5%，肺部肿瘤RR 29.4%，DCR 76.5%。24例肺非鳞癌患者中，胸水治疗RR 75%，肺部肿瘤RR 37.5%，DCR 83.3%。胸水治疗RR与肺部肿瘤DCR有相关性。90.2%患者生活质量获得改善。治疗不良反应轻。结论：顺铂胸腔灌注联合静脉吉西他滨或培美曲塞化疗治疗非小细胞肺癌并恶性胸水的临床疗效肯定，不良反应轻。
목적：관찰순박흉강관주연합정맥길서타빈혹배미곡새화료치료비소세포폐암병악성흉수적림상료효。방법：41례비소세포폐암병악성흉수환자，순박안75mg/m2흉강관주，동시행상규제량적정맥길서타빈혹배미곡새화료，평개폐부종류화흉수적공제정황、생활질량급불량반응。결과：17례폐린암환자중，흉수치료RR 76.5%，폐부종류RR 29.4%，DCR 76.5%。24례폐비린암환자중，흉수치료RR 75%，폐부종류RR 37.5%，DCR 83.3%。흉수치료RR여폐부종류DCR유상관성。90.2%환자생활질량획득개선。치료불량반응경。결론：순박흉강관주연합정맥길서타빈혹배미곡새화료치료비소세포폐암병악성흉수적림상료효긍정，불량반응경。
Objective:To observe the clinical efficacy of intrapleural cisplatin therapy combined with intravenous chemotherapy with gemcitabine or pemetrexed in the treatment of non-small cell lung cancer-mediated malignant pleural effusion. Methods:All 41 patients with non -small cell lung cancer -mediated malignant pleural effusion were treated with pleural cavity perfusion with cisplatin 75mg/m2 combined with intravenous chemotherapy with gem-citabine(1250mg/m2,d1,8)on squamous carcinoma or pemetrexed(500mg/m2,d1)on non-squamous carcinoma. The therapeutic efficacy,quality of life and adverse reaction were evaluated. Results:Overall response rate( RR)of pleural effusion was 76. 5%,RR of lung cancer was 29. 4%,disease control rate(DCR)of lung cancer was 76. 5% in 17 cases with pulmonary squamous. Within 24 cases of pulmonary non-squamous carcinoma,RR of pleural effusion was 75%;RR of lung tumor was 37. 5%,DCR of lung cancer was 83. 3%. RR of pleural effusion was relevant to DCR of lung cancer. 90. 2% patientˊs quality of life was improved after treatment. Adverse reaction was mild. Conclusion:The remedy of cisplatin pleural cavity perfusion combined with intravenous chemotherapy with gemcitabine or peme-trexed in the treatment of non-small cell lung cancer with malignant pleural effusion showed good clinically effect and mild adverse reaction.