CAJ | 학술논문

1,25 (OH)2维生素D3是维生素D在人体内的活性形式,它通过细胞内特异性维生素D受体发挥着广泛的作用.最近研究表明,1,25(OH)2维生素D3通过与维生素D受体结合,能够保护足细胞,抑制系膜细胞增殖,调节系膜细胞凋亡,延缓肾小管间质纤维化,抑制炎症细胞,减少炎症因子,抑制肾素-血管紧张素系统,对慢性肾脏病起到保护肾功能作用.该文就近年1,25(OH)2维生素D3及维生素D受体在慢性肾脏病中的研究进展作一综述.
1,25 (OH)2유생소D3시유생소D재인체내적활성형식,타통과세포내특이성유생소D수체발휘착엄범적작용.최근연구표명,1,25(OH)2유생소D3통과여유생소D수체결합,능구보호족세포,억제계막세포증식,조절계막세포조망,연완신소관간질섬유화,억제염증세포,감소염증인자,억제신소-혈관긴장소계통,대만성신장병기도보호신공능작용.해문취근년1,25(OH)2유생소D3급유생소D수체재만성신장병중적연구진전작일종술.
1,25 (OH)2 D vitamin3 is the activated form of vitamin D in human body.Mediated by specific vitamin D receptor, 1,25(OH) 2 vitamin D3 plays an important role in many physiological and pathological process.In recent years, researches have shown that 1,25 (OH) 2 vitamin D3 can protect podocytes, inhibit the proliferation of mesenteric cells, regulate the apoptosis of mesenteric cells, anti-inflammation, and have negative effect in rennin-angiotensin system, so as to protect the renal function.This paper reviews the progress of the effect of 1,25(OH)2 vitamin D3 and vitamin D receptor in chronic renal disease.