CAJ | 학술논문

目的：探讨维、汉民族间H型高血压患者血清同型半胱氨酸水平与动脉硬化的相关性。方法选择2011年1月-2013年12月住院确诊的原发性高血压患者513例作为研究对象，其中H型高血压（Hcy≥10μmol/L）252例，单纯高血压（Hcy＜10μmol/L）261例，维吾尔族194例，汉族319例，收集患者的基本资料、baPWV、PPI、昼夜血压节律、生化指标等临床数据，分析新疆维、汉民族间Hcy与baPWV、PPI、昼夜血压节律的关系。结果（1）维吾尔族、汉族H型高血压患者的[U1]baP-WV、PPI均高于单纯高血压组（P＜0.05）；而夜间收缩压、舒张压下降率低于单纯高血压组，差异有统计学意义（P＜0.05）；（2）[U2]维吾尔族与汉族H型高血压组比较：维吾尔族BMI、糖化血红蛋白、PPI均高于汉族，而汉族Hcy水平高于维吾尔族，差异具有统计学意义（P＜0.05）；（3）以维吾尔族动脉硬化相关指标为因变量的Logistic回归分析结果显示：年龄是左右baPWV升高的危险因素（P<0.05）；年龄、HbAlc是PPI的危险因素；[U3][A4]以汉族患者动脉硬化相关指标为因变量的Logistic回归分析结果显示：Hcy、年龄是左右baPWV、PPI、夜间收缩压下降率的危险因素（P<0.05）；Hcy是夜间舒张压下降率的危险因素。结论维汉民族H型高血压患者动脉硬化程度较单纯高血压患者更为严重，且维汉民族之间存在差异；Hcy水平升高是汉族H型高血压人群动脉硬化的主要危险因素。
목적：탐토유、한민족간H형고혈압환자혈청동형반광안산수평여동맥경화적상관성。방법선택2011년1월-2013년12월주원학진적원발성고혈압환자513례작위연구대상，기중H형고혈압（Hcy≥10μmol/L）252례，단순고혈압（Hcy＜10μmol/L）261례，유오이족194례，한족319례，수집환자적기본자료、baPWV、PPI、주야혈압절률、생화지표등림상수거，분석신강유、한민족간Hcy여baPWV、PPI、주야혈압절률적관계。결과（1）유오이족、한족H형고혈압환자적[U1]baP-WV、PPI균고우단순고혈압조（P＜0.05）；이야간수축압、서장압하강솔저우단순고혈압조，차이유통계학의의（P＜0.05）；（2）[U2]유오이족여한족H형고혈압조비교：유오이족BMI、당화혈홍단백、PPI균고우한족，이한족Hcy수평고우유오이족，차이구유통계학의의（P＜0.05）；（3）이유오이족동맥경화상관지표위인변량적Logistic회귀분석결과현시：년령시좌우baPWV승고적위험인소（P<0.05）；년령、HbAlc시PPI적위험인소；[U3][A4]이한족환자동맥경화상관지표위인변량적Logistic회귀분석결과현시：Hcy、년령시좌우baPWV、PPI、야간수축압하강솔적위험인소（P<0.05）；Hcy시야간서장압하강솔적위험인소。결론유한민족H형고혈압환자동맥경화정도교단순고혈압환자경위엄중，차유한민족지간존재차이；Hcy수평승고시한족H형고혈압인군동맥경화적주요위험인소。
Objective To discuss the correlation between serum homocysteine level and arteriosclerosis for Uygur and Han patients with H-type hypertension. Methods 513 patients who were diagnosed with essential hypertension from January 2011 to December 2013 were selected as objects, including 252 patients with H-type hypertension (Hcy≥10μmol/L), 261 patients with simple hypertension (Hcy<10μmol/L), 194 Uygur patients and 319 Han patients. Basic information, biochemical indicators, baPWV, PPI, circadian rhythm of blood pressure and other clinical data of all patients were collected. The correlation among all those indexes between Xinjiang Uygur and Han nationalities was analyzed. Results (1)baPWV and PPI in Uygur patients and Han paitents with H-type hypertension were higher than those in the simple hypertension group (P<0.05);while the decrease rates of nighttime systolic and diastolic pressure were lower than those in the simple hypertension group, and the difference was statistically significant (P<0.05);(2) Between Uygur patients group and Han patients group with H-type hypertension:BMI, glycosylated hemoglobin and PPI in Uygur patients group were higher than those in Han patients group, homocysteine level was lower, and the difference was statistically significant (P<0.05); (3) the logistic regression analysis when dependent variables was arteriosclerosis-related indicators of Uygur patients showed that age was a risk factors for the increase of baPWV (P<0.05);age and HbAlc were risk factors for PPI;The logistic repression analysis with arteriosclerosis-related indicators of Han patients as the dependent variables showed that Hcy and age were all risk factors for the increase of baPWV、PPI and decrease rate of nighttime systolic pressure (P<0.05); Hcy was the risk factor for the decrease rate of nighttime diastolic pressure. Conclusion The atherosclerosis degree of Uygur and Han patients with H-type hypertension is more severe compared with the patients under simple pressure, and there is a difference between Uygur and Han nationalities;the increase of homocysteine level is a main risk factors for the atherosclerosis in Han patients with H-type hypertension.