CAJ | 학술논문

目的：研究VCMP方案治疗多发性骨髓瘤（ multiple myeloma，MM）的临床疗效及安全性。方法：回顾分析汉中市人民医院2007年6月至2012年12月收治的66例多发性骨髓瘤患者的临床资料。所有患者均采用VCMP方案，化疗1~12个疗程不等，疗效判断采用EBMT标准并按WHO标准判断不良反应。结果：完全缓解27例，部分缓解20例，轻微反应10例，疾病进展5例，4例无变化，总有效率为71.2%。结论：以VC-MP为主的化疗方案治疗初诊多发性骨髓瘤安全有效，能够延长患者的无病生存期。各亚型间有效率无明显差别，对于不适合做造血干细胞移植的老年患者亦安全有效，不良反应轻微可耐受。
목적：연구VCMP방안치료다발성골수류（ multiple myeloma，MM）적림상료효급안전성。방법：회고분석한중시인민의원2007년6월지2012년12월수치적66례다발성골수류환자적림상자료。소유환자균채용VCMP방안，화료1~12개료정불등，료효판단채용EBMT표준병안WHO표준판단불량반응。결과：완전완해27례，부분완해20례，경미반응10례，질병진전5례，4례무변화，총유효솔위71.2%。결론：이VC-MP위주적화료방안치료초진다발성골수류안전유효，능구연장환자적무병생존기。각아형간유효솔무명현차별，대우불괄합주조혈간세포이식적노년환자역안전유효，불량반응경미가내수。
Objective:To discuss the clinical efficacy and safety of VCMP regimen in treatment of patients with multiple myeloma( MM). Methods:A retrospective analysis was made on clinical data of 66 cases of multiple myelo-ma patients from June 2007 to December 2012 in our hospital. All patients were treated with VCMP regimen chemo-therapy for 1 to 12 course. Results:Of 66 patients,27 achieved complete remission,20 partial remission,10 minor re-sponse,5 progress disease,4 no response,with an overall effective rate of 71. 2%. Conclusion:For newly diagnosed multiple myeloma,VCMP chemotherapy is safe and effective. It could prolong disease free survival,and subtypes show no significant difference in overall effective rate. It is also safe and effective for elderly patients who are not suitable for undergoing hematopoietic stem cell transplantation. Adverse reactions are mild and tolerable.